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dc.contributor.authorSato, Wataruen
dc.contributor.authorToichi, Motomien
dc.contributor.authorUono, Shotaen
dc.contributor.authorKochiyama, Takanorien
dc.contributor.alternative佐藤, 弥ja
dc.date.accessioned2012-08-21T00:48:57Z-
dc.date.available2012-08-21T00:48:57Z-
dc.date.issued2012-08-13-
dc.identifier.issn1471-2202-
dc.identifier.urihttp://hdl.handle.net/2433/159107-
dc.description自閉症スペクトラム障害でミラーニューロン回路の不全. 京都大学プレスリリース. 2012-08-15.ja
dc.description.abstractBACKGROUND: Impairment of social interaction via facial expressions represents a core clinical feature of autism spectrum disorders (ASD). However, the neural correlates of this dysfunction remain unidentified. Because this dysfunction is manifested in real-life situations, we hypothesized that the observation of dynamic, compared with static, facial expressions would reveal abnormal brain functioning in individuals with ASD. We presented dynamic and static facial expressions of fear and happiness to individuals with high-functioning ASD and to age- and sex-matched typically developing controls and recorded their brain activities using functional magnetic resonance imaging (fMRI). RESULT: Regional analysis revealed reduced activation of several brain regions in the ASD group compared with controls in response to dynamic versus static facial expressions, including the middle temporal gyrus (MTG), fusiform gyrus, amygdala, medial prefrontal cortex, and inferior frontal gyrus (IFG). Dynamic causal modeling analyses revealed that bi-directional effective connectivity involving the primary visual cortex-MTG-IFG circuit was enhanced in response to dynamic as compared with static facial expressions in the control group. Group comparisons revealed that all these modulatory effects were weaker in the ASD group than in the control group. CONCLUSIONS: These results suggest that weak activity and connectivity of the social brain network underlie the impairment in social interaction involving dynamic facial expressions in individuals with ASD.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherBioMed Central Ltd.en
dc.rightsCopyright © 2012 Sato et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.subjectAmygdalaen
dc.subjectAutism spectrum disordersen
dc.subjectASDen
dc.subjectDynamic facial expressionen
dc.subjectFusiform gyrusen
dc.subjectInferior frontal gyrusen
dc.subjectMedial prefrontal cortexen
dc.subjectMiddle temporal gyrus/superior temporal sulcusen
dc.subjectMirror neuron systemen
dc.titleImpaired social brain network for processing dynamic facial expressions in autism spectrum disordersen
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleBMC Neuroscienceen
dc.identifier.volume13-
dc.relation.doi10.1186/1471-2202-13-99-
dc.textversionpublisher-
dc.identifier.artnum99-
dc.identifier.pmid22889284-
dc.relation.urlhttps://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2012/120815_1.htm-
dcterms.accessRightsopen access-
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