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タイトル: Relationship between peripheral airway function and patient-reported outcomes in COPD: a cross-sectional study.
著者: Haruna, Akane
Oga, Toru  KAKEN_id
Muro, Shigeo  KAKEN_id
Ohara, Tadashi
Sato, Susumu  KAKEN_id  orcid https://orcid.org/0000-0002-9626-1090 (unconfirmed)
Marumo, Satoshi
Kinose, Daisuke
Terada, Kunihiko
Nishioka, Michiyoshi
Ogawa, Emiko
Hoshino, Yuma
Hirai, Toyohiro  KAKEN_id
Chin, Kazuo  KAKEN_id
Mishima, Michiaki
著者名の別形: 小賀, 徹
発行日: 7-Mar-2010
出版者: BioMed Central Ltd.
誌名: BMC pulmonary medicine
巻: 10
論文番号: 10
抄録: [Background]Health status, dyspnea and psychological status are important clinical outcomes in chronic obstructive pulmonary disease (COPD). However, forced expiratory volume in one second (FEV1) measured by spirometry, the standard measurement of airflow limitation, has only a weak relationship with these outcomes in COPD. Recently, in addition to spirometry, impulse oscillometry (IOS) measuring lung resistance (R) and reactance (X) is increasingly being used to assess pulmonary functional impairment. [Methods]We aimed to identify relationships between IOS measurements and patient-reported outcomes in 65 outpatients with stable COPD. We performed pulmonary function testing, IOS, high-resolution computed tomography (CT), and assessment of health status using the St. George's Respiratory Questionnaire (SGRQ), dyspnea using the Medical Research Council (MRC) scale and psychological status using the Hospital Anxiety and Depression Scale (HADS). We then investigated the relationships between these parameters. For the IOS measurements, we used lung resistance at 5 and 20 Hz (R5 and R20, respectively) and reactance at 5 Hz (X5). Because R5 and R20 are regarded as reflecting total and proximal airway resistance, respectively, the fall in resistance from R5 to R20 (R5-R20) was used as a surrogate for the resistance of peripheral airways. X5 was also considered to represent peripheral airway abnormalities. [Results]R5-R20 and X5 were significantly correlated with the SGRQ and the MRC. These correlation coefficients were greater than when using other objective measurements of pulmonary function, R20 on the IOS and CT instead of R5-R20 and X5. Multiple regression analyses showed that R5-R20 or X5 most significantly accounted for the SGRQ and MRC scores. [Conclusions]IOS measurements, especially indices of peripheral airway function, are significantly correlated with health status and dyspnea in patients with COPD. Therefore, in addition to its simplicity and non-invasiveness, IOS may be a useful clinical tool not only for detecting pulmonary functional impairment, but also to some extent at least estimating the patient's quality of daily life and well-being.
著作権等: © 2010 Haruna et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use,distribution, and reproduction in any medium, provided the original work is properly cited.
URI: http://hdl.handle.net/2433/159488
DOI(出版社版): 10.1186/1471-2466-10-10
PubMed ID: 20205936
出現コレクション:学術雑誌掲載論文等

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