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dc.contributor.author | Ishiguro, H | en |
dc.contributor.author | Takashima, S | en |
dc.contributor.author | Yoshimura, K | en |
dc.contributor.author | Yano, I | en |
dc.contributor.author | Yamamoto, T | en |
dc.contributor.author | Niimi, M | en |
dc.contributor.author | Yamashiro, H | en |
dc.contributor.author | Ueno, T | en |
dc.contributor.author | Takeuchi, M | en |
dc.contributor.author | Sugie, T | en |
dc.contributor.author | Yanagihara, K | en |
dc.contributor.author | Toi, M | en |
dc.contributor.author | Fukushima, M | en |
dc.contributor.alternative | 石黒, 洋 | ja |
dc.date.accessioned | 2012-10-15T07:49:29Z | - |
dc.date.available | 2012-10-15T07:49:29Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0941-4355 | - |
dc.identifier.uri | http://hdl.handle.net/2433/160053 | - |
dc.description.abstract | [Purpose]:Frozen gloves (FG) are effective in preventing docetaxel-induced nail toxicity (DNT), but uncomfortable. The preventive effect of FG for DNT was compared using a standard (−25 to −30°C) or more comfortable (−10 to −20°C) preparation. [Methods]:Breast cancer patients receiving docetaxel were eligible. Each patient wore an FG (prepared at −10 to −20°C for 90 min) for 60 min without replacement on the right hand. The left hand was protected by standard methods (FG prepared at −25 to −30°C overnight and worn for 90 min with replacement at 45 min). The primary endpoint was DNT occurrence at 5 months. Secondary endpoints included docetaxel exposure [cumulative dose and area under the blood concentration time curve (AUC)] until DNT occurrence and discomfort from FG. The pharmacokinetics of docetaxel was assessed. [Results]:From 23 patients enrolled between December 2006 and June 2010, seven who received docetaxel for less than 5 months were excluded from evaluation. The median accumulated docetaxel dose was 700 mg/m2 (340–1430 mg/m2). Within 5 months of FG use, none developed protocol-defined DNT in either hand. Two patients (13%) developed DNT at 7.2 and 7.3 months, respectively, both at −10 to −20°C. In the control hand (−25 to −30°C), discomfort occurred in 92% of the cycles, compared to 15% in the experimental hand (−10 to −20°C). Five patients (22%) experienced pain at −25 to −30°C, but none did at −10 to −20°C. The degree of docetaxel exposure was not related to DNT occurrence in our study. [Conclusion]:A convenient preparation of FG at −10 to −20°C is almost as effective as a standard preparation at −25 to −30°C, with significantly less discomfort. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Verlag | en |
dc.rights | © The Author(s) 2011. This article is published with open access at Springerlink.com | en |
dc.subject | Chemotherapy | en |
dc.subject | Docetaxel | en |
dc.subject | Frozen glove | en |
dc.subject | Nail toxicity | en |
dc.subject | Pharmacokinetics | en |
dc.title | Degree of freezing does not affect efficacy of frozen gloves for prevention of docetaxel-induced nail toxicity in breast cancer patients. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10996793 | - |
dc.identifier.jtitle | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer | en |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 2017 | - |
dc.identifier.epage | 2024 | - |
dc.relation.doi | 10.1007/s00520-011-1308-4 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 22086405 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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