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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| srep00642.pdf | 2.4 MB | Adobe PDF | 見る/開く |
| タイトル: | In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues. |
| 著者: | Nambu, Yukiko Hayashi, Tatsunari Jang, Kyoung-Jin Aoki, Koji Mano, Hiroto Nakano, Keiko Osato, Motomi Takahashi, Katsu  Itoh, Katsuhiko Teramukai, Satoshi Komori, Toshihisa Fujita, Jun Ito, Yoshiaki Shimizu, Akira  Sugai, Manabu |
| 著者名の別形: | 菅井, 学 |
| キーワード: | Differentiation Immunogenetics Autoimmunity |
| 発行日: | 7-Sep-2012 |
| 出版者: | Nature Publishing Group |
| 誌名: | Scientific reports |
| 巻: | 2 |
| 論文番号: | 642 |
| 抄録: | Mutually exclusive cell fate determination of CD4 helper or CD8 killer T cells occurs in the thymus. These T-cell subsets are not believed to redirect other lineages. Here we showed that retinoic acid and transforming growth factor-β1 promoted the differentiation of CD8αα T cells from CD4 T cells in a Runx3-dependent manner. These cells were inferred to belong to immunoregulatory populations because subpopulations of CD8αα+TCRαβ T cells are known to suppress activated T cells, and mice with Runx3(-/-) T cells showed defects during recovery from experimental allergic encephalomyelitis. Our results demonstrate that CD4 T cells play fundamental roles in controlling immune reactions through promotion and attenuation. We accordingly anticipate that clarifying the mechanisms underlying this process will provide insights leading to autoimmune and immunodeficiency disease therapies. |
| 著作権等: | This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
| URI: | http://hdl.handle.net/2433/160369 |
| DOI(出版社版): | 10.1038/srep00642 |
| PubMed ID: | 22962636 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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