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Title: In situ differentiation of CD8αα Τ cells from CD4 T cells in peripheral lymphoid tissues.
Authors: Nambu, Yukiko
Hayashi, Tatsunari
Jang, Kyoung-Jin
Aoki, Koji
Mano, Hiroto
Nakano, Keiko
Osato, Motomi
Takahashi, Katsu  kyouindb  KAKEN_id
Itoh, Katsuhiko  kyouindb  KAKEN_id
Teramukai, Satoshi
Komori, Toshihisa
Fujita, Jun  KAKEN_id
Ito, Yoshiaki
Shimizu, Akira  kyouindb  KAKEN_id
Sugai, Manabu  KAKEN_id
Author's alias: 菅井, 学
Keywords: Differentiation
Issue Date: 7-Sep-2012
Publisher: Nature Publishing Group
Journal title: Scientific reports
Volume: 2
Thesis number: 642
Abstract: Mutually exclusive cell fate determination of CD4 helper or CD8 killer T cells occurs in the thymus. These T-cell subsets are not believed to redirect other lineages. Here we showed that retinoic acid and transforming growth factor-β1 promoted the differentiation of CD8αα T cells from CD4 T cells in a Runx3-dependent manner. These cells were inferred to belong to immunoregulatory populations because subpopulations of CD8αα+TCRαβ T cells are known to suppress activated T cells, and mice with Runx3(-/-) T cells showed defects during recovery from experimental allergic encephalomyelitis. Our results demonstrate that CD4 T cells play fundamental roles in controlling immune reactions through promotion and attenuation. We accordingly anticipate that clarifying the mechanisms underlying this process will provide insights leading to autoimmune and immunodeficiency disease therapies.
Rights: This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit
DOI(Published Version): 10.1038/srep00642
PubMed ID: 22962636
Appears in Collections:Journal Articles

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