N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters.

Uno, Takuya; Kobayashi, Yusuke; Takemoto, Yoshiji

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http://hdl.handle.net/2433/160376

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DCフィールド	値	言語
dc.contributor.author	Uno, Takuya	en
dc.contributor.author	Kobayashi, Yusuke	en
dc.contributor.author	Takemoto, Yoshiji	en
dc.contributor.alternative	竹本, 佳司	ja
dc.date.accessioned	2012-10-24T02:08:09Z	-
dc.date.available	2012-10-24T02:08:09Z	-
dc.date.issued	2012-09-10	-
dc.identifier.issn	1860-5397	-
dc.identifier.uri	http://hdl.handle.net/2433/160376	-
dc.description.abstract	An efficient catalytic synthesis of α-amino-β-keto esters has been newly developed. Cross-coupling of various aldehydes with α-imino ester, catalyzed by N-heterocyclic carbene, leads chemoselectively to α-amino-β-keto esters in moderate to good yields with high atom efficiency. The reaction mechanism is discussed, and it is proposed that the α-amino-β-keto esters are formed under thermodynamic control.	en
dc.format.mimetype	application/pdf	-
dc.language.iso	eng	-
dc.publisher	Beilstein-Institut	en
dc.rights	© 2012 Uno et al; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)	en
dc.subject	α-amino-β-keto esters	en
dc.subject	cross-aza-benzoin	en
dc.subject	α-imino ester	en
dc.subject	N-heterocyclic carbenes	en
dc.subject	organocatalysis	en
dc.subject	umpolung reactions	en
dc.title	N-Heterocyclic carbene-catalyzed direct cross-aza-benzoin reaction: Efficient synthesis of α-amino-β-keto esters.	en
dc.type	journal article	-
dc.type.niitype	Journal Article	-
dc.identifier.jtitle	Beilstein journal of organic chemistry	en
dc.identifier.volume	8	-
dc.identifier.spage	1499	-
dc.identifier.epage	1504	-
dc.relation.doi	10.3762/bjoc.8.169	-
dc.textversion	publisher	-
dc.identifier.pmid	23019484	-
dcterms.accessRights	open access	-
出現コレクション:	学術雑誌掲載論文等

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