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Title: Alexithymia and reduced white matter integrity in schizophrenia: A diffusion tensor imaging study on impaired emotional self-awareness.
Authors: Kubota, Manabu
Miyata, Jun  kyouindb  KAKEN_id
Sasamoto, Akihiko  kyouindb  KAKEN_id
Kawada, Ryosaku
Fujimoto, Shinsuke
Tanaka, Yusuke
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Fukuyama, Hidenao  KAKEN_id
Takahashi, Hidehiko  kyouindb  KAKEN_id
Murai, Toshiya  kyouindb  KAKEN_id
Author's alias: 久保田, 学
宮田, 淳
Keywords: MRI
Tract-based spatial statistics
TAS-20
Corpus callosum
Superior longitudinal fasciculus
Inferior longitudinal fasciculus
Issue Date: Nov-2012
Publisher: Elsevier B.V.
Journal title: Schizophrenia research
Volume: 141
Issue: 2-3
Start page: 137
End page: 143
Abstract: Alexithymia is characterized by deficits in emotional self-awareness. A number of previous studies have revealed impaired emotional self-awareness in schizophrenia. Although the pathology of schizophrenia is thought to involve disrupted white matter integrity, its relationship with alexithymia remains unclear. The present study investigated associations between alexithymia and white matter integrity, to seek the neural basis of impaired emotional self-awareness in schizophrenia. Forty-four patients with schizophrenia and 44 age-, gender- and predicted IQ level-matched healthy controls underwent diffusion-weighted imaging. Alexithymia was assessed using the 20-item Toronto Alexithymia Scale (TAS-20). We applied tract-based spatial statistics to investigate the correlation between the TAS-20 total score and white matter fractional anisotropy (FA). TAS-20 scores were significantly higher in patients than in controls. In the patient group only, FA was negatively correlated with the TAS-20 total score in the corpus callosum, mostly the left part of the superior and inferior longitudinal fasciculi, the inferior occipito-frontal fasciculus, the anterior and posterior thalamic radiation, and the precuneus white matter. These results suggest that schizophrenia is associated with alexithymia, and that reduced white matter integrity within these regions constitutes an important pathology underlying impaired self-emotional awareness in schizophrenia.
Rights: © 2012 Elsevier B.V
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/160386
DOI(Published Version): 10.1016/j.schres.2012.08.026
PubMed ID: 22986045
Appears in Collections:Journal Articles

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