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タイトル: | Alexithymia and reduced white matter integrity in schizophrenia: A diffusion tensor imaging study on impaired emotional self-awareness. |
著者: | Kubota, Manabu Miyata, Jun ![]() ![]() Sasamoto, Akihiko ![]() Kawada, Ryosaku Fujimoto, Shinsuke Tanaka, Yusuke Sawamoto, Nobukatsu ![]() ![]() Fukuyama, Hidenao ![]() Takahashi, Hidehiko ![]() Murai, Toshiya ![]() ![]() |
著者名の別形: | 久保田, 学 宮田, 淳 |
キーワード: | MRI Tract-based spatial statistics TAS-20 Corpus callosum Superior longitudinal fasciculus Inferior longitudinal fasciculus |
発行日: | Nov-2012 |
出版者: | Elsevier B.V. |
誌名: | Schizophrenia research |
巻: | 141 |
号: | 2-3 |
開始ページ: | 137 |
終了ページ: | 143 |
抄録: | Alexithymia is characterized by deficits in emotional self-awareness. A number of previous studies have revealed impaired emotional self-awareness in schizophrenia. Although the pathology of schizophrenia is thought to involve disrupted white matter integrity, its relationship with alexithymia remains unclear. The present study investigated associations between alexithymia and white matter integrity, to seek the neural basis of impaired emotional self-awareness in schizophrenia. Forty-four patients with schizophrenia and 44 age-, gender- and predicted IQ level-matched healthy controls underwent diffusion-weighted imaging. Alexithymia was assessed using the 20-item Toronto Alexithymia Scale (TAS-20). We applied tract-based spatial statistics to investigate the correlation between the TAS-20 total score and white matter fractional anisotropy (FA). TAS-20 scores were significantly higher in patients than in controls. In the patient group only, FA was negatively correlated with the TAS-20 total score in the corpus callosum, mostly the left part of the superior and inferior longitudinal fasciculi, the inferior occipito-frontal fasciculus, the anterior and posterior thalamic radiation, and the precuneus white matter. These results suggest that schizophrenia is associated with alexithymia, and that reduced white matter integrity within these regions constitutes an important pathology underlying impaired self-emotional awareness in schizophrenia. |
著作権等: | © 2012 Elsevier B.V この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/160386 |
DOI(出版社版): | 10.1016/j.schres.2012.08.026 |
PubMed ID: | 22986045 |
出現コレクション: | 学術雑誌掲載論文等 |
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