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dc.contributor.author | Tamura, Hiroshi | en |
dc.contributor.author | Tsujikawa, Akitaka | en |
dc.contributor.author | Yamashiro, Kenji | en |
dc.contributor.author | Akagi-Kurashige, Yumiko | en |
dc.contributor.author | Nakata, Isao | en |
dc.contributor.author | Nakanishi, Hideo | en |
dc.contributor.author | Hayashi, Hisako | en |
dc.contributor.author | Ooto, Sotaro | en |
dc.contributor.author | Otani, Atsushi | en |
dc.contributor.author | Yoshimura, Nagahisa | en |
dc.contributor.alternative | 田村, 寛 | ja |
dc.date.accessioned | 2012-10-25T04:20:11Z | - |
dc.date.available | 2012-10-25T04:20:11Z | - |
dc.date.issued | 2012-09 | - |
dc.identifier.issn | 0002-9394 | - |
dc.identifier.uri | http://hdl.handle.net/2433/160394 | - |
dc.description.abstract | [Purpose]: To study the association of ARMS2 A69S genotype with the development of exudative age-related macular degeneration (AMD) in the unaffected fellow eye and to estimate the duration until the development of AMD in the second eye. [Design]: Retrospective cohort study. [Methods]: We retrospectively reviewed 326 patients who had exudative AMD in at least 1 eye, genotyping of ARMS2 A69S, and a minimum follow-up of 2 years. Survival analysis and Cox proportional hazard regression analysis were used to examine the association between candidate factors and the duration until the development of AMD in the second eye. [Results]: One hundred nineteen patients (36.5%) had bilateral exudative AMD at the initial visit. A risk allele of ARMS2 A69S was more frequently seen in patients with bilateral AMD (P = .0270) than in those with unilateral AMD. Of the 207 unilateral AMD patients, 23 (11.1%) had AMD in the fellow eye after a mean duration of 56.3 ± 40.4 months. Fellow-eye involvement was associated with ARMS2 A69S genotype (hazard ratio [HR], 2.673; P = .0013), age (HR, 1.102; P = .0005), and smoking history (HR, 0.680; P = .3663). As HRs indicate, correlation of genotype (2.673) was as high as that of 10-year aging (1.10210 = 2.641). Survival analysis revealed that patients with risk homozygous (TT) genotype had second-eye involvement significantly earlier than those with other genotypes (P = .0028). When the observation duration reached 120 months, second-eye involvement had developed in 50%, 6.6%, and 11.2% of the TT, GT, and GG cohorts, respectively. [Conclusion]: ARMS2 A69S genotype is associated with second-eye involvement of exudative AMD and with the period between first- and second-eye involvements. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | © 2012 Elsevier Inc. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | age-related macular degeneration | en |
dc.subject | second eye | en |
dc.subject | genotype | en |
dc.subject | ARMS2 | en |
dc.title | Association of ARMS2 genotype with bilateral involvement of exudative age-related macular degeneration. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11523017 | - |
dc.identifier.jtitle | American journal of ophthalmology | en |
dc.identifier.volume | 154 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 542 | - |
dc.identifier.epage | 548.e1 | - |
dc.relation.doi | 10.1016/j.ajo.2012.03.042 | - |
dc.textversion | author | - |
dc.identifier.pmid | 22809783 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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