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dc.contributor.authorYamazaki, Tja
dc.contributor.authorYamori, Mja
dc.contributor.authorIshizaki, Tja
dc.contributor.authorAsai, Kja
dc.contributor.authorGoto, Kja
dc.contributor.authorTakahashi, Kja
dc.contributor.authorNakayama, Tja
dc.contributor.authorBessho, Kja
dc.contributor.alternative山崎, 亨ja
dc.contributor.alternative家森, 正志ja
dc.date.accessioned2012-11-05T05:02:00Z-
dc.date.available2012-11-05T05:02:00Z-
dc.date.issued2012-11ja
dc.identifier.issn0901-5027ja
dc.identifier.urihttp://hdl.handle.net/2433/160871-
dc.description.abstractThis study estimated the cumulative incidence and risk ratio for osteonecrosis of the jaw (ONJ) after tooth extraction in patients with and without administration of bisphosphonates (BP) and identified potential risk factors for bisphosphonate-induced osteonecrosis of the jaw (BIONJ). A cohort study was conducted in all patients undergoing tooth extraction at a university hospital in Japan from April 2006 to June 2009. Of 3216 patients, 126 had BP administration, of whom 5 (3.9%, 95% confidence interval (CI): 1.2-9.2) developed ONJ, versus 1 (0.032%, 95% CI: 0.00081-0.18) among 3090 patients without BP administration. BP administration was associated with the development of ONJ after tooth extraction, with an unadjusted risk ratio of 122.6 (95% CI: 14.4-1041.8). When stratified by age and route of BP administration, the risk ratio for ONJ patients aged 65 years or older with intravenous BP administration compared to those without was 200.2 (95% CI: 23.8-1679.4, P<0.001). Patients receiving BP showed a significant association between the incidence of BIONJ and alveolar bone loss score. The risk of ONJ is higher in patients with than without BP administration, particularly intravenous administration. Severe periodontitis might be a risk factor for BIONJ.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherElsevier Ltd.ja
dc.rights© 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd.ja
dc.rightsこの論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.ja
dc.subjectalveolar bone lossja
dc.subjectbisphosphonateja
dc.subjectincidenceja
dc.subjectjawja
dc.subjectosteonecrosisja
dc.subjectrelative riskja
dc.subjecttooth extractionja
dc.titleIncreased incidence of osteonecrosis of the jaw after tooth extraction in patients treated with bisphosphonates: a cohort study.ja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA10682150ja
dc.identifier.jtitleInternational journal of oral and maxillofacial surgeryja
dc.identifier.volume41ja
dc.identifier.issue11ja
dc.identifier.spage1397ja
dc.identifier.epage1403ja
dc.relation.doi10.1016/j.ijom.2012.06.020ja
dc.textversionauthorja
dc.identifier.pmid22840716ja
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