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dc.contributor.author | Nakanishi, Yuki | en |
dc.contributor.author | Seno, Hiroshi | en |
dc.contributor.author | Fukuoka, Ayumi | en |
dc.contributor.author | Ueo, Taro | en |
dc.contributor.author | Yamaga, Yuichi | en |
dc.contributor.author | Maruno, Takahisa | en |
dc.contributor.author | Nakanishi, Naoko | en |
dc.contributor.author | Kanda, Keitaro | en |
dc.contributor.author | Komekado, Hideyuki | en |
dc.contributor.author | Kawada, Mayumi | en |
dc.contributor.author | Isomura, Akihiro | en |
dc.contributor.author | Kawada, Kenji | en |
dc.contributor.author | Sakai, Yoshiharu | en |
dc.contributor.author | Yanagita, Motoko | en |
dc.contributor.author | Kageyama, Ryoichiro | en |
dc.contributor.author | Kawaguchi, Yoshiya | en |
dc.contributor.author | Taketo, Makoto M | en |
dc.contributor.author | Yonehara, Shin | en |
dc.contributor.author | Chiba, Tsutomu | en |
dc.contributor.alternative | 妹尾, 浩 | ja |
dc.date.accessioned | 2012-12-04T06:47:39Z | - |
dc.date.available | 2012-12-04T06:47:39Z | - |
dc.date.issued | 2012-12-02 | - |
dc.identifier.issn | 1061-4036 | - |
dc.identifier.uri | http://hdl.handle.net/2433/163077 | - |
dc.description | 癌幹細胞を特定するマーカー同定に成功 : 新世代の癌治療法開発に期待.京都大学プレスリリース.2012-12-03. | ja |
dc.description.abstract | There is great interest in tumor stem cells (TSCs) as potential therapeutic targets; however, cancer therapies targeting TSCs are limited. A drawback is that TSC markers are often shared by normal stem cells (NSCs)1–4; thus, therapies that target these markers may cause severe injury to normal tissues. To identify a potential TSC-specific marker, we focused on doublecortin-like kinase 1 (Dclk1). Dclk1 was reported as a candidate NSC marker in the gut5, 6, but recent reports have implicated it as a marker of differentiated cells (for example, Tuft cells)7, 8. Using lineage-tracing experiments, we show here that Dclk1 does not mark NSCs in the intestine but instead marks TSCs that continuously produce tumor progeny in the polyps of ApcMin/+ mice. Specific ablation of Dclk1-positive TSCs resulted in a marked regression of polyps without apparent damage to the normal intestine. Our data suggest the potential for developing a therapy for colorectal cancer based on targeting Dclk1-positive TSCs. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. | en |
dc.rights | 許諾条件により本文は2013-06-02に公開. | ja |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | tumor initiating cell | en |
dc.subject | cancer stem cell | en |
dc.subject | lineage tracing | en |
dc.subject | colon cancer | en |
dc.subject | Dcamkl1 | en |
dc.title | Dclk1 distinguishes between tumor and normal stem cells in the intestine | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA1084279X | - |
dc.identifier.jtitle | Nature Genetics | en |
dc.identifier.volume | 45 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 98 | - |
dc.identifier.epage | 103 | - |
dc.relation.doi | 10.1038/ng.2481 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2013-06-02 | - |
dc.identifier.pmid | 23202126 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2012/121203_1.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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