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ファイル | 記述 | サイズ | フォーマット | |
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j.jjcc.2012.07.014.pdf | 291.39 kB | Adobe PDF | 見る/開く |
タイトル: | Current concept of reverse cholesterol transport and novel strategy for atheroprotection. |
著者: | Ono, Koh https://orcid.org/0000-0002-4163-980X (unconfirmed) |
著者名の別形: | 尾野, 亘 |
キーワード: | High-density lipoprotein cholesterol Low-density lipoprotein cholesterol Statin Coronary heart disease Atherosclerosis MicroRNA |
発行日: | Nov-2012 |
出版者: | Elsevier Ireland Ltd. |
誌名: | Journal of cardiology |
巻: | 60 |
号: | 5 |
開始ページ: | 339 |
終了ページ: | 343 |
抄録: | Elevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of coronary heart disease (CHD), but pharmacologic therapy to decrease LDL-C significantly reduces the risk of cardiovascular events. Despite the effectiveness of statin therapy, there remains significant residual cardiovascular risk. A low plasma concentration of high-density lipoprotein cholesterol (HDL-C) is associated with increased risk of CHD. Moreover, recent studies have shown that HDL-C levels during statin treatment remain an independent predictor of the risk of cardiovascular events. However, recent clinical trials aimed at reducing CHD risk by raising HDL-C levels have not shown satisfactory results and it is becoming evident that a functional HDL-C is a more desirable target than simply elevating its level. This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs. |
著作権等: | © 2012 Japanese College of Cardiology. Published by Elsevier Ireland Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/163080 |
DOI(出版社版): | 10.1016/j.jjcc.2012.07.014 |
PubMed ID: | 23063661 |
出現コレクション: | 学術雑誌掲載論文等 |
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