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タイトル: Current concept of reverse cholesterol transport and novel strategy for atheroprotection.
著者: Ono, Koh  kyouindb researcher_resolver
著者名の別形: 尾野,  亘
キーワード: High-density lipoprotein cholesterol
Low-density lipoprotein cholesterol
Statin
Coronary heart disease
Atherosclerosis
MicroRNA
発行日: Nov-2012
出版者: Elsevier Ireland Ltd.
誌名: Journal of cardiology
巻: 60
号: 5
開始ページ: 339
終了ページ: 343
抄録: Elevated levels of low-density lipoprotein cholesterol (LDL-C) increase the risk of coronary heart disease (CHD), but pharmacologic therapy to decrease LDL-C significantly reduces the risk of cardiovascular events. Despite the effectiveness of statin therapy, there remains significant residual cardiovascular risk. A low plasma concentration of high-density lipoprotein cholesterol (HDL-C) is associated with increased risk of CHD. Moreover, recent studies have shown that HDL-C levels during statin treatment remain an independent predictor of the risk of cardiovascular events. However, recent clinical trials aimed at reducing CHD risk by raising HDL-C levels have not shown satisfactory results and it is becoming evident that a functional HDL-C is a more desirable target than simply elevating its level. This review summarizes the function of HDL-C in reverse cholesterol transfer from peripheral tissue and discusses the latest HDL-targeting therapeutic strategies including the manipulation of microRNAs.
著作権等: © 2012 Japanese College of Cardiology. Published by Elsevier Ireland Ltd.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/163080
DOI(出版社版): 10.1016/j.jjcc.2012.07.014
PubMed ID: 23063661
出現コレクション:学術雑誌掲載論文等

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