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ファイル | 記述 | サイズ | フォーマット | |
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j.celrep.2012.11.012.pdf | 1.19 MB | Adobe PDF | 見る/開く |
タイトル: | Accelerating the Tempo of the Segmentation Clock by Reducing the Number of Introns in the Hes7 Gene |
著者: | Harima, Yukiko Takashima, Yoshiki Ueda, Yuriko Ohtsuka, Toshiyuki Kageyama, Ryoichiro https://orcid.org/0000-0002-5985-1120 (unconfirmed) |
著者名の別形: | 影山, 龍一郎 |
発行日: | 31-Jan-2013 |
出版者: | Elsevier |
誌名: | Cell Reports |
巻: | 3 |
抄録: | Periodic somite segmentation is controlled by the cyclic gene Hes7, whose oscillatory expression depends upon negative feedback with a delayed timing. The mechanism that regulates the pace of segmentation remains to be determined, but mathematical modeling has predicted that negative feedback with shorter delays would give rise to dampened but more rapid oscillations. Here, we show that reducing the number of introns within the Hes7 gene shortens the delay and results in a more rapid tempo of both Hes7 oscillation and somite segmentation, increasing the number of somites and vertebrae in the cervical and upper thoracic region. These results suggest that the number of introns is important for the appropriate tempo of oscillatory expression and that Hes7 is a key regulator of the pace of the segmentation clock. |
記述: | Hes7遺伝子のイントロン削減による分節時計の加速化. 京都大学プレスリリース. 2012-12-07. |
著作権等: | Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved. |
URI: | http://hdl.handle.net/2433/163492 |
DOI(出版社版): | 10.1016/j.celrep.2012.11.012 |
PubMed ID: | 23219549 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/121207_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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