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dc.contributor.author | 神田, 英輝 | ja |
dc.contributor.author | 舛井, 覚 | ja |
dc.contributor.author | 山田, 泰司 | ja |
dc.contributor.author | 有馬, 公伸 | ja |
dc.contributor.author | 杉村, 芳樹 | ja |
dc.contributor.alternative | Kanda, Hideki | en |
dc.contributor.alternative | Masui, Satoru | en |
dc.contributor.alternative | Yamada, Yasushi | en |
dc.contributor.alternative | Arima, Kiminobu | en |
dc.contributor.alternative | Sugimura, Yoshiki | en |
dc.date.accessioned | 2012-12-20T01:33:09Z | - |
dc.date.available | 2012-12-20T01:33:09Z | - |
dc.date.issued | 2012-11 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/166342 | - |
dc.description.abstract | Patients diagnosed with metastatic renal cell carcinoma (mRCC) are currently treated with oral tyrosine kinase inhibitors (TKIs). Sunitinib malate (Sutent R Pfizer INC) is an oral multitargeted TKI and is the mainstay of therapy for mRCC patients in Japan. Although it shows a high therapeutic response and prolonged survival rates, sunitinib exhibits a novel and distinct toxicity profile that requires appropriate monitoring and management. Therefore, the physician needs to understand the modalities to detect and cope with such adverse events to effectively treat the patient. We summarized the management of the most frequent and clinically significant adverse events of sunitinib treatment. Myelotoxicity, especially thrombocytopenia seemed to be the most common and severe toxicity (73% all grade, 36.8%, ≧grade 3). The incidences of thyroid dysfunction, fatigue, hypertension, hand-foot syndrome, nausea, diarrhea and oral changes were reviewed. The incidences of ≧grade 3 adverse events and dose reduction were higher than those in western reports. In our institution, fever was frequently observed (up to 63.1%). When the patient is at high risk of sunitinib assosicated adverse events, dose reduction from the beginning of sunitinib therapy may be useful. To maintain the patient’s quality of life and for long-term administration of the sunitinib, it is worth while to modulate the sunitinib administration schedule for each patient. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.rights | 許諾条件により本文は2013-12-01に公開 | ja |
dc.subject | Renal cell carcinoma | en |
dc.subject | Sunitinib | en |
dc.subject | Adverse events | en |
dc.subject.ndc | 494.9 | - |
dc.title | Sunitinib投与に関する副作用対策 | ja |
dc.title.alternative | Management of Sunitinib-Associated Adverse Events | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 58 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 639 | - |
dc.identifier.epage | 646 | - |
dc.textversion | publisher | - |
dc.sortkey | 11 | - |
dc.address | 三重大学医学部付属病院腎泌尿器外科 | ja |
dc.address | 三重大学医学部付属病院腎泌尿器外科 | ja |
dc.address | 三重大学医学部付属病院腎泌尿器外科 | ja |
dc.address | 三重大学医学部付属病院腎泌尿器外科 | ja |
dc.address | 三重大学医学部付属病院腎泌尿器外科 | ja |
dc.startdate.bitstreamsavailable | 2013-12-01 | - |
dc.address.alternative | The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine | en |
dc.address.alternative | The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine | en |
dc.address.alternative | The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine | en |
dc.address.alternative | The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine | en |
dc.address.alternative | The Department of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine | en |
dc.identifier.pmid | 23254793 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.58 No.11 |
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