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Title: Developmental patterns of chimpanzee cerebral tissues provide important clues for understanding the remarkable enlargement of the human brain.
Authors: Sakai, Tomoko
Matsui, Mie
Mikami, Akichika
Malkova, Ludise
Hamada, Yuzuru
Tomonaga, Masaki  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9319-6991 (unconfirmed)
Suzuki, Juri  kyouindb  KAKEN_id
Tanaka, Masayuki
Miyabe-Nishiwaki, Takako  kyouindb  KAKEN_id
Makishima, Haruyuki
Nakatsukasa, Masato  kyouindb  KAKEN_id
Matsuzawa, Tetsuro  kyouindb  KAKEN_id
Author's alias: 酒井, 朋子
Keywords: brain evolution
brain development
chimpanzees
encephalization
infancy
magnetic resonance imaging
Issue Date: 22-Feb-2013
Publisher: Royal Society Publishing
Journal title: Proceedings of the Royal Society B: Biological Sciences
Volume: 280
Issue: 1753
Abstract: Developmental prolongation is thought to contribute to the remarkable brain enlargement observed in modern humans (Homo sapiens). However, the developmental trajectories of cerebral tissues have not been explored in chimpanzees (Pan troglodytes), even though they are our closest living relatives. To address this lack of information, the development of cerebral tissues was tracked in growing chimpanzees during infancy and the juvenile stage, using three-dimensional magnetic resonance imaging and compared with that of humans and rhesus macaques (Macaca mulatta). Overall, cerebral development in chimpanzees demonstrated less maturity and a more protracted course during prepuberty, as observed in humans but not in macaques. However, the rapid increase in cerebral total volume and proportional dynamic change in the cerebral tissue in humans during early infancy, when white matter volume increases dramatically, did not occur in chimpanzees. A dynamic reorganization of cerebral tissues of the brain during early infancy, driven mainly by enhancement of neuronal connectivity, is likely to have emerged in the human lineage after the split between humans and chimpanzees and to have promoted the increase in brain volume in humans. Our findings may lead to powerful insights into the ontogenetic mechanism underlying human brain enlargement.
Description: 世界で初めてチンパンジーの大脳の成長様式の解明に成功 : チンパンジーの脳成長からヒト知性の誕生の秘密に迫る. 京都大学プレスリリース. 2012-12-21.
Rights: © 2012 The Author(s)
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
URI: http://hdl.handle.net/2433/167637
DOI(Published Version): 10.1098/rspb.2012.2398
PubMed ID: 23256194
Related Link: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/121221_1.htm
Appears in Collections:Journal Articles

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