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Title: Enteral supplement enriched with glutamine, fiber, and oligosaccharide attenuates experimental colitis in mice.
Authors: Joo, Erina
Yamane, Shunsuke  kyouindb  KAKEN_id
Hamasaki, Akihiro
Harada, Norio  kyouindb  KAKEN_id
Matsunaga, Tetsuro
Muraoka, Atsushi
Suzuki, Kazuyo  kyouindb  KAKEN_id  orcid (unconfirmed)
Nasteska, Daniela
Fukushima, Toru
Hayashi, Tatsuya  kyouindb  KAKEN_id  orcid (unconfirmed)
Tsuji, Hidemi
Shide, Kenichiro
Tsuda, Kinsuke
Inagaki, Nobuya  kyouindb  KAKEN_id
Author's alias: 城尾, 恵里奈
稲垣, 暢也
Keywords: GFO
Ulcerative colitis
Dextran sulfate sodium
Glucagon-like peptide
Issue Date: Mar-2013
Publisher: Elsevier Inc.
Journal title: Nutrition
Volume: 29
Issue: 3
Start page: 549
End page: 555
Abstract: [Objective]Ulcerative colitis is a chronic recurrent disease characterized by acute inflammation of the colonic mucosa. In Japan, a dietary supplementation product enriched with glutamine, dietary fiber, and oligosaccharide (GFO) is widely applied for enteral nutrition support. These three components have been suggested to improve intestinal health. In this study, we investigated whether GFO has suppressive effects on mucosal damage in ulcerative colitis in an experimental mouse model. [Methods]C57BL/6 mice received 2.5% dextran sulfate sodium in drinking water for 5 d to induce colitis. Then, they were given 0.25 mL of GFO or a 20% glucose solution twice daily for 10 d. Another set of mice receiving unaltered drinking water was used as the normal control group. [Results]The body weight loss and disease activity index were significantly lower in the GFO-treated mice compared with the glucose-treated mice (P < 0.05). The decrease in colon length induced by dextran sulfate sodium was significantly alleviated in GFO-treated mice compared with glucose-treated mice (P < 0.01). In addition, the histologic findings showed that intestinal inflammation was significantly attenuated in mice treated with GFO. Furthermore, treatment with GFO significantly inhibited the dextran sulfate sodium–induced increase in the mRNA expression of interleukin-1β. [Conclusion]These results suggest that GFO has potential therapeutic value as an adjunct therapy for ulcerative colitis.
Rights: © 2013 Elsevier Inc.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.nut.2012.09.007
PubMed ID: 23274091
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