Downloads: 193

Files in This Item:
File Description SizeFormat 
hdy.2012.28.pdf9.25 MBAdobe PDFView/Open
Title: Repetitive sequences originating from the centromere constitute large-scale heterochromatin in the telomere region in the siamang, a small ape.
Authors: Koga, A  kyouindb  KAKEN_id
Hirai, Y
Hara, T
Hirai, H  kyouindb  KAKEN_id
Author's alias: 平井, 啓久
Keywords: Heterochromatin
Tandem repeats
Telomere
Alpha satellite
Hominoidea
Primates
Issue Date: Sep-2012
Publisher: Nature Publishing Group
Journal title: Heredity
Volume: 109
Issue: 3
Start page: 180
End page: 187
Abstract: Chromosomes of the siamang Symphalangus syndactylus (a small ape) carry large-scale heterochromatic structures at their ends. These structures look similar, by chromosome C-banding, to chromosome-end heterochromatin found in chimpanzee, bonobo and gorilla (African great apes), of which a major component is tandem repeats of 32-bp-long, AT-rich units. In the present study, we identified repetitive sequences that are a major component of the siamang heterochromatin. Their repeat units are 171 bp in length, and exhibit sequence similarity to alpha satellite DNA, a major component of the centromeres in primates. Thus, the large-scale heterochromatic structures have different origins between the great apes and the small ape. The presence of alpha satellite DNA in the telomere region has previously been reported in the white-cheeked gibbon Nomascus leucogenys, another small ape species. There is, however, a difference in the size of the telomere-region alpha satellite DNA, which is far larger in the siamang. It is not known whether the sequences of these two species (of different genera) have a common origin because the phylogenetic relationship of genera within the small ape family is still not clear. Possible evolutionary scenarios are discussed.
Rights: © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited.
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
URI: http://hdl.handle.net/2433/172554
DOI(Published Version): 10.1038/hdy.2012.28
PubMed ID: 22669075
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.