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Title: Three Groups in the 28 Joints for Rheumatoid Arthritis Synovitis - Analysis Using More than 17,000 Assessments in the KURAMA Database.
Authors: Terao, Chikashi  kyouindb  KAKEN_id
Hashimoto, Motomu  kyouindb  KAKEN_id
Yamamoto, Keiichi
Murakami, Kosaku  kyouindb  KAKEN_id  orcid (unconfirmed)
Ohmura, Koichiro  kyouindb  KAKEN_id
Nakashima, Ran
Yamakawa, Noriyuki
Yoshifuji, Hajime  kyouindb  KAKEN_id  orcid (unconfirmed)
Yukawa, Naoichiro  KAKEN_id
Kawabata, Daisuke
Usui, Takashi
Yoshitomi, Hiroyuki  kyouindb  KAKEN_id
Furu, Moritoshi  kyouindb  KAKEN_id
Yamada, Ryo  kyouindb  KAKEN_id  orcid (unconfirmed)
Matsuda, Fumihiko
Ito, Hiromu  kyouindb  KAKEN_id
Fujii, Takao  KAKEN_id
Mimori, Tsuneyo  kyouindb  KAKEN_id
Author's alias: 寺尾, 知可史
Issue Date: 12-Mar-2013
Publisher: Public Library of Science
Journal title: PloS one
Volume: 8
Issue: 3
Thesis number: e59341
Abstract: Rheumatoid arthritis (RA) is a joint-destructive autoimmune disease. Three composite indices evaluating the same 28 joints are commonly used for the evaluation of RA activity. However, the relationship between, and the frequency of, the joint involvements are still not fully understood. Here, we obtained and analyzed 17,311 assessments for 28 joints in 1,314 patients with RA from 2005 to 2011 from electronic clinical chart templates stored in the KURAMA (Kyoto University Rheumatoid Arthritis Management Alliance) database. Affected rates for swelling and tenderness were assessed for each of the 28 joints and compared between two different sets of RA patients. Correlations of joint symptoms were analyzed for swellings and tenderness using kappa coefficient and eigen vectors by principal component analysis. As a result, we found that joint affected rates greatly varied from joint to joint both for tenderness and swelling for the two sets. Right wrist joint is the most affected joint of the 28 joints. Tenderness and swellings are well correlated in the same joints except for the shoulder joints. Patients with RA tended to demonstrate right-dominant joint involvement and joint destruction. We also found that RA synovitis could be classified into three categories of joints in the correlation analyses: large joints with wrist joints, PIP joints, and MCP joints. Clustering analysis based on distribution of synovitis revealed that patients with RA could be classified into six subgroups. We confirmed the symmetric joint involvement in RA. Our results suggested that RA synovitis can be classified into subgroups and that several different mechanisms may underlie the pathophysiology in RA synovitis.
Rights: © 2013 Terao et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI(Published Version): 10.1371/journal.pone.0059341
PubMed ID: 23555018
Appears in Collections:Journal Articles

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