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ファイル | 記述 | サイズ | フォーマット | |
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j.pneurobio.2012.04.002.pdf | 21.75 MB | Adobe PDF | 見る/開く |
タイトル: | Space representation in the prefrontal cortex. |
著者: | Funahashi, Shintaro |
著者名の別形: | 船橋, 新太郎 |
キーワード: | Prefrontal cortex Delayed response Spatial working memory Spatial information processing |
発行日: | Apr-2013 |
出版者: | Elsevier Ltd. |
誌名: | Progress in neurobiology |
巻: | 103 |
開始ページ: | 131 |
終了ページ: | 155 |
抄録: | The representation of space and its function in the prefrontal cortex have been examined using a variety of behavioral tasks. Among them, since the delayed-response task requires the temporary maintenance of spatial information, this task has been used to examine the mechanisms of spatial representation. In addition, the concept of working memory to explain prefrontal functions has helped us to understand the nature and functions of space representation in the prefrontal cortex. The detailed analysis of delay-period activity observed in spatial working memory tasks has provided important information for understanding space representation in the prefrontal cortex. Directional delay-period activity has been shown to be a neural correlate of the mechanism for temporarily maintaining information and represent spatial information for the visual cue and the saccade. In addition, many task-related prefrontal neurons exhibit spatially selective activities. These neurons are also important components of spatial information processing. In fact, information flow from sensory-related neurons to motor-related neurons has been demonstrated, along with a change in spatial representation as the trial progresses. The dynamic functional interactions among neurons exhibiting different task-related activities and representing different aspects of information could play an essential role in information processing. In addition, information provided from other cortical or subcortical areas might also be necessary for the representation of space in the prefrontal cortex. To better understand the representation of space and its function in the prefrontal cortex, we need to understand the nature of functional interactions between the prefrontal cortex and other cortical and subcortical areas. |
著作権等: | © 2012 Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/173914 |
DOI(出版社版): | 10.1016/j.pneurobio.2012.04.002 |
PubMed ID: | 22521602 |
出現コレクション: | 学術雑誌掲載論文等 |
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