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Title: Thalamic mediodorsal nucleus and working memory.
Authors: Watanabe, Yumiko
Funahashi, Shintaro  KAKEN_id
Author's alias: 船橋, 新太郎
Keywords: Thalamic mediodorsal nucleus
Prefrontal cortex
Spatial working memory
Retrospective information
Prospective information
Issue Date: Jan-2012
Publisher: Elsevier Ltd.
Journal title: Neuroscience and biobehavioral reviews
Volume: 36
Issue: 1
Start page: 134
End page: 142
Abstract: Working memory is a dynamic neural system for temporarily maintaining and processing information. The prefrontal cortex (PFC) plays an important role in working memory. However, several evidences indicate that the thalamic mediodorsal nucleus (MD) also participates in working memory. Neurophysiological studies revealed that MD neurons exhibit sustained delay activity, which is considered to be a neural correlate of the temporary maintenance of information. Most MD neurons with delay activity represented information regarding motor responses, whereas some represented information regarding visual cues, suggesting that the MD participates more in prospective aspects of working memory, in contrast to the PFC, in which a minority participates in prospective aspects of working memory. A population vector analysis revealed that the transformation of sensory-to-motor information occurred during the earlier phase of the delay period in the MD compared with the PFC. These results indicate that reverberating neural circuits constructed by reciprocal connections between the MD and the PFC could be an important component for constructing prospective information in the PFC.
Rights: © 2011 Elsevier Ltd.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.neubiorev.2011.05.003
PubMed ID: 21605592
Appears in Collections:Journal Articles

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