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ファイル | 記述 | サイズ | フォーマット | |
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j.neubiorev.2011.05.003.pdf | 2.13 MB | Adobe PDF | 見る/開く |
タイトル: | Thalamic mediodorsal nucleus and working memory. |
著者: | Watanabe, Yumiko Funahashi, Shintaro |
著者名の別形: | 船橋, 新太郎 |
キーワード: | Thalamic mediodorsal nucleus Prefrontal cortex Spatial working memory Delayed-response Retrospective information Prospective information |
発行日: | Jan-2012 |
出版者: | Elsevier Ltd. |
誌名: | Neuroscience and biobehavioral reviews |
巻: | 36 |
号: | 1 |
開始ページ: | 134 |
終了ページ: | 142 |
抄録: | Working memory is a dynamic neural system for temporarily maintaining and processing information. The prefrontal cortex (PFC) plays an important role in working memory. However, several evidences indicate that the thalamic mediodorsal nucleus (MD) also participates in working memory. Neurophysiological studies revealed that MD neurons exhibit sustained delay activity, which is considered to be a neural correlate of the temporary maintenance of information. Most MD neurons with delay activity represented information regarding motor responses, whereas some represented information regarding visual cues, suggesting that the MD participates more in prospective aspects of working memory, in contrast to the PFC, in which a minority participates in prospective aspects of working memory. A population vector analysis revealed that the transformation of sensory-to-motor information occurred during the earlier phase of the delay period in the MD compared with the PFC. These results indicate that reverberating neural circuits constructed by reciprocal connections between the MD and the PFC could be an important component for constructing prospective information in the PFC. |
著作権等: | © 2011 Elsevier Ltd. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/173915 |
DOI(出版社版): | 10.1016/j.neubiorev.2011.05.003 |
PubMed ID: | 21605592 |
出現コレクション: | 学術雑誌掲載論文等 |
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