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dc.contributor.authorMorinaga, Hironobuen
dc.contributor.authorTakenaka, Tomohiroen
dc.contributor.authorHashiya, Fumitakaen
dc.contributor.authorKizaki, Seiichiroen
dc.contributor.authorHashiya, Kaorien
dc.contributor.authorBando, Toshikazuen
dc.contributor.authorSugiyama, Hiroshien
dc.contributor.alternative杉山, 弘ja
dc.date.accessioned2013-06-05T02:40:35Z-
dc.date.available2013-06-05T02:40:35Z-
dc.date.issued2013-04-01-
dc.identifier.issn0305-1048-
dc.identifier.urihttp://hdl.handle.net/2433/174316-
dc.description.abstractElectron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherOxford University Press.en
dc.rights© The Author(s) 2013. Published by Oxford University Press.en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleSequence-specific electron injection into DNA from an intermolecular electron donor.en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.ncidAA00760269-
dc.identifier.jtitleNucleic acids researchen
dc.identifier.volume41-
dc.identifier.issue8-
dc.identifier.spage4724-
dc.identifier.epage4728-
dc.relation.doi10.1093/nar/gkt123-
dc.textversionpublisher-
dc.identifier.pmid23439569-
dcterms.accessRightsopen access-
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