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dc.contributor.authorMorinaga, Hironobuen
dc.contributor.authorTakenaka, Tomohiroen
dc.contributor.authorHashiya, Fumitakaen
dc.contributor.authorKizaki, Seiichiroen
dc.contributor.authorHashiya, Kaorien
dc.contributor.authorBando, Toshikazuen
dc.contributor.authorSugiyama, Hiroshien
dc.contributor.alternative杉山, 弘ja
dc.description.abstractElectron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection.en
dc.publisherOxford University Press.en
dc.rights© The Author(s) 2013. Published by Oxford University Press.en
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.titleSequence-specific electron injection into DNA from an intermolecular electron donor.en
dc.typejournal article-
dc.type.niitypeJournal Article-
dc.identifier.jtitleNucleic acids researchen
dcterms.accessRightsopen access-
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