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dc.contributor.author | Morinaga, Hironobu | en |
dc.contributor.author | Takenaka, Tomohiro | en |
dc.contributor.author | Hashiya, Fumitaka | en |
dc.contributor.author | Kizaki, Seiichiro | en |
dc.contributor.author | Hashiya, Kaori | en |
dc.contributor.author | Bando, Toshikazu | en |
dc.contributor.author | Sugiyama, Hiroshi | en |
dc.contributor.alternative | 杉山, 弘 | ja |
dc.date.accessioned | 2013-06-05T02:40:35Z | - |
dc.date.available | 2013-06-05T02:40:35Z | - |
dc.date.issued | 2013-04-01 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/2433/174316 | - |
dc.description.abstract | Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press. | en |
dc.rights | © The Author(s) 2013. Published by Oxford University Press. | en |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.title | Sequence-specific electron injection into DNA from an intermolecular electron donor. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00760269 | - |
dc.identifier.jtitle | Nucleic acids research | en |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 4724 | - |
dc.identifier.epage | 4728 | - |
dc.relation.doi | 10.1093/nar/gkt123 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 23439569 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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