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Title: Overactive bladder symptom severity is associated with falls in community-dwelling adults: LOHAS study.
Authors: Kurita, Noriaki
Yamazaki, Shin
Fukumori, Norio
Otoshi, Kenichi
Otani, Koji
Sekiguchi, Miho
Onishi, Yoshihiro
Takegami, Misa
Ono, Rei
Horie, Shigeo
Konno, Shin-Ichi
Kikuchi, Shin-Ichi
Fukuhara, Shunichi  kyouindb  KAKEN_id
Author's alias: 栗田, 宜明
福原, 俊一
Issue Date: May-2013
Publisher: BMJ Publishing Group Ltd.
Journal title: BMJ open
Volume: 3
Issue: 5
Thesis number: e002413
Abstract: [Objectives] To examine the association between overactive bladder (OAB) symptom severity and falls and the contribution of OAB symptoms to falls in a community-dwelling population. [Design] Cross-sectional study. [Setting] 2 Japanese municipalities. [Participants] A total of 2505 residents aged over 40 years, who participated in health check-ups conducted in 2010. OAB symptom assessed via overactive bladder symptom score (OABSS) was divided into six categories based on distribution and Japanese clinical guidelines. Mobility problems and depressive symptoms were assessed via the Timed Up and Go test and the short form of the Center for Epidemiologic Studies Depression Scale, respectively. [Primary outcome measures] Self-reported any fall and frequent fall (≥2) over the 1-month period. Independent contributions to any fall and frequent falls were assessed via logistic regression to generate population-attributable fractions (PAFs), assuming separate causal relationships between OAB symptoms, mobility problems and depressive symptoms and any or frequent falls. [Results] Among the total 1350 participants (mean age: 68.3 years) analysed, any fall and frequent falls were reported by 12.7% and 4.4%, respectively. Compared with no OABSS score, moderate-to-severe OAB and mild OAB were associated with any fall (adjusted ORs 2.37 (95% CI 1.12 to 4.98) and 2.51 (95% CI 1.14 to 5.52), respectively). Moderate-to-severe OAB was also strongly associated with frequent falls (adjusted OR 6.90 (95% CI 1.50 to 31.6)). Adjusted PAFs of OAB symptoms were 40.7% (95% CI 0.7% to 64.6%) for any fall and 67.7% (95% CI −23.1% to 91.5%) for frequent falls. Further, these point estimates were similar to or larger than those of mobility problems and depressive symptoms. [Conclusions] An association does indeed exist between OAB symptom severity and falls, and OAB symptoms might be important contributors to falls among community-dwelling adults. Further longitudinal studies are warranted to examine whether or not OAB symptoms predict risk of future falls and fall-related injuries.
Rights: This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0/ and http://creativecommons.org/licenses/by-nc/3.0/legalcode
URI: http://hdl.handle.net/2433/175243
DOI(Published Version): 10.1136/bmjopen-2012-002413
PubMed ID: 23645923
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