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Title: Multisynaptic projections from the ventrolateral prefrontal cortex to hand and mouth representations of the monkey primary motor cortex.
Authors: Miyachi, Shigehiro  kyouindb  KAKEN_id
Hirata, Yoshihiro
Inoue, Ken-Ichi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-5683-5280 (unconfirmed)
Lu, Xiaofeng
Nambu, Atsushi
Takada, Masahiko  kyouindb  KAKEN_id
Author's alias: 宮地, 重弘
Keywords: Rabies virus
Area 46
Orbitofrontal cortex
Somatotopy
Forelimb
Orofacial
Issue Date: Jul-2013
Publisher: Elsevier Ireland.
Journal title: Neuroscience research
Volume: 76
Issue: 3
Start page: 141
End page: 149
Abstract: Different sectors of the prefrontal cortex have distinct neuronal connections with higher-order sensory areas and/or limbic structures and are related to diverse aspects of cognitive functions, such as visual working memory and reward-based decision-making. Recent studies have revealed that the prefrontal cortex (PF), especially the lateral PF, is also involved in motor control. Hence, different sectors of the PF may contribute to motor behaviors with distinct body parts. To test this hypothesis anatomically, we examined the patterns of multisynaptic projections from the PF to regions of the primary motor cortex (MI) that represent the arm, hand, and mouth, using retrograde transsynaptic transport of rabies virus. Four days after rabies injections into the hand or mouth region, particularly dense neuron labeling was observed in the ventrolateral PF, including the convexity part of ventral area 46. After the rabies injections into the mouth region, another dense cluster of labeled neurons was seen in the orbitofrontal cortex (area 13). By contrast, rabies labeling of PF neurons was rather sparse in the arm-injection cases. The present results suggest that the PF-MI multisynaptic projections may be organized such that the MI hand and mouth regions preferentially receive cognitive information for execution of elaborate motor actions.
Rights: © 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society.
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
URI: http://hdl.handle.net/2433/175588
DOI(Published Version): 10.1016/j.neures.2013.04.004
PubMed ID: 23664864
Appears in Collections:Journal Articles

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