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タイトル: | Effect of olprinone on liver microstructure in rat partial liver transplantation. |
著者: | Yamanaka, Kenya Hatano, Etsuro Iguchi, Khota Yamamoto, Gen Sato, Motohiko Toriguchi, Kan Tanabe, Kazutaka Takemoto, Kenji Nakamura, Kojiro Koyama, Noriyuki Narita, Masato Nagata, Hiromitsu Taura, Kojiro Uemoto, Shinji |
著者名の別形: | 波多野, 悦朗 |
キーワード: | Olprinone Small-for-size syndrome Liver injury Microstructure |
発行日: | Jul-2013 |
出版者: | Elsevier Inc. |
誌名: | The Journal of surgical research |
巻: | 183 |
号: | 1 |
開始ページ: | 391 |
終了ページ: | 396 |
抄録: | [Background]Donor safety is a major concern in living-donor liver transplantation. However, partial grafts do not meet the functional demands of recipients and lead to small-for-size syndrome (SFSS). In a previous study, we showed that olprinone (OLP), a selective phosphodiesterase ІІІ inhibitor, up-regulates endothelial nitric oxide synthase level in the liver and attenuates shear stress, sinusoidal endothelial cell injury, and hepatocyte apoptosis after excessive liver resection in a rat model. We aimed to examine whether OLP treatment has beneficial effects on SFSS in a rat model of partial liver transplantation (PLT). [Methods]We performed experiments in a rat model of 30% PLT. In the OLP group, we inserted an osmotic pump with OLP into the peritoneal cavity 48 h before liver graft sampling. Recipient rats were not treated with OLP. We examined the liver microstructure by electron microscopy and biochemical examination, and determined the 7-d survival of recipients. [Results]In the OLP group 1 h after PLT, the sinusoidal endothelial cells of the liver were well preserved and we observed few vacuolar structures in hepatocytes. The total serum bilirubin level 1 wk after PLT tended to be lower in the OLP group than in the controls, and the liver microstructures were also well preserved in the OLP group. The probability of survival in the OLP group (100%; 14 of 14 rats) was significantly higher than that in the control group (75%; 15 of 20 rats). [Conclusions]Olprinone treatment was demonstrated to have therapeutic potential to overcome SFSS. |
著作権等: | © 2013 Elsevier Inc. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/175671 |
DOI(出版社版): | 10.1016/j.jss.2012.11.033 |
PubMed ID: | 23246009 |
出現コレクション: | 学術雑誌掲載論文等 |
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