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タイトル: | Suppression of acute rejection by administration of prostaglandin E2 receptor subtype 4 agonist in rat organ transplantation models. |
著者: | Okamoto, Tatsuya Okamoto, Shinya Fujimoto, Yasuhiro Tabata, Yasuhiko Uemoto, Shinji |
著者名の別形: | 岡本, 竜弥 上本, 伸二 |
キーワード: | Prostaglandin E2 receptor subtype 4 agonist Acute rejection Inflammation Interferon-gamma Heart transplantation Small bowel transplantation |
発行日: | Aug-2013 |
出版者: | Elsevier Inc. |
誌名: | The Journal of surgical research |
巻: | 183 |
号: | 2 |
開始ページ: | 852 |
終了ページ: | 859 |
抄録: | [Background] Prostaglandin E2 (PGE2) receptor subtype 4 (EP4) signaling is known to modulate the inflammation process. Several studies have demonstrated the potential utility of EP4-selective agonists for the management of autoimmune and inflammatory diseases. In the present study, we assessed the immunosuppressive efficacy of a selective EP4 agonist in experimental rat organ transplantation models. [Methods] We continuously injected a selective EP4 agonist (CAY10580) by subcutaneous insertion of infuser pumps into recipient rats that underwent heterotopic heart and small bowel transplantation. [Results] The administration of EP4 agonist significantly delayed cardiac allograft survival and delayed the onset of rejection in both the cardiac and intestinal allografts. Expression of proinflammatory cytokines of interferon-gamma was suppressed by the treatment compared with the vehicle-treated group. Furthermore, the expression of suppressor of cytokine signaling-1, a known intracellular regulation factor of IFN-gamma, was also down-regulated compared with the control group. [Conclusions] These results suggest that selective EP4 agonists represent a novel class of immune-modulator drugs that could be useful for the management of acute allogeneic rejection. |
著作権等: | © 2013 Elsevier Inc. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/177376 |
DOI(出版社版): | 10.1016/j.jss.2013.01.039 |
PubMed ID: | 23478083 |
出現コレクション: | 学術雑誌掲載論文等 |
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