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ファイル | 記述 | サイズ | フォーマット | |
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j.neubiorev.2013.07.006.pdf | 1.44 MB | Adobe PDF | 見る/開く |
タイトル: | Habenula and ADHD: Convergence on time. |
著者: | Lee, Young-A Goto, Yukiori |
著者名の別形: | 後藤, 幸織 |
キーワード: | ADHD Habenula Circadian rhythm Sleep Time perception Animal model |
発行日: | Sep-2013 |
出版者: | Elsevier Ltd. |
誌名: | Neuroscience and biobehavioral reviews |
巻: | 37 |
号: | 8 |
開始ページ: | 1801 |
終了ページ: | 1809 |
抄録: | Attention deficit/hyperactivity disorder (ADHD) is a childhood-onset psychiatric condition characterized by hyperactivity, impulsivity, and attention deficit. In addition to these core symptoms, accumulating evidence suggests that ADHD may also involve alterations in circadian rhythms, sleep disturbance, and time perception. The habenula is a brain region transmitting limbic information to the midbrain monoamine systems and is thereby involved in the regulation of monoamine release in such target brain areas as the striatum, where it is part of the biological substrates that process time perception. The habenula is additionally a part of the circadian rhythm network and is involved in sleep regulation. Our recent study provides a new insight that a habenula lesion created early in development produces behavioral and brain alterations resembling those observed in ADHD. We propose that the habenula may be a promising target for understanding the pathogenesis of ADHD. |
著作権等: | © 2013 Elsevier Ltd. この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/178664 |
DOI(出版社版): | 10.1016/j.neubiorev.2013.07.006 |
PubMed ID: | 23876287 |
出現コレクション: | 学術雑誌掲載論文等 |
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