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j.febslet.2013.06.026.pdf | 359.25 kB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Kanehisa, Minoru | en |
dc.contributor.alternative | 金久, 實 | ja |
dc.date.accessioned | 2013-09-26T05:19:18Z | - |
dc.date.available | 2013-09-26T05:19:18Z | - |
dc.date.issued | 2013-09-02 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/2433/178762 | - |
dc.description.abstract | There is a tendency that a unit of enzyme genes in an operon-like structure in the prokaryotic genome encodes enzymes that catalyze a series of consecutive reactions in a metabolic pathway. Our recent analysis shows that this and other genomic units correspond to chemical units reflecting chemical logic of organic reactions. From all known metabolic pathways in the KEGG database we identified chemical units, called reaction modules, as the conserved sequences of chemical structure transformation patterns of small molecules. The extracted patterns suggest co-evolution of genomic units and chemical units. While the core of the metabolic network may have evolved with mechanisms involving individual enzymes and reactions, its extension may have been driven by modular units of enzymes and reactions. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | en |
dc.rights | © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Evolution of metabolism | en |
dc.subject | Metabolic pathway | en |
dc.subject | Enzyme cluster | en |
dc.subject | Reaction module | en |
dc.subject | KEGG database | en |
dc.title | Chemical and genomic evolution of enzyme-catalyzed reaction networks. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00642943 | - |
dc.identifier.jtitle | FEBS letters | en |
dc.identifier.volume | 587 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | 2731 | - |
dc.identifier.epage | 2737 | - |
dc.relation.doi | 10.1016/j.febslet.2013.06.026 | - |
dc.textversion | author | - |
dc.identifier.pmid | 23816707 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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