ムスカリン受容体拮抗薬無効の高齢女性に対するβ3アドレナリン受容体作動薬の有用性

Abstract

In the present study, we investigated the efficacy of mirabegron, a β3-adrenergic agonist, in patients aged ＞70 years who did not respond to treatment with an anticholinergic agent. From February 2012 to May 2012, we examined 37 patients who did not respond to treatment with an anticholinergic agent. We assessed the overactive bladder symptom score (OABSS), thirst, and constipation at baseline, as well as at 3 and 6 months from thestart of drug administration. Theme an ageof thefe malepatie nts was 79.9±6.08 years. The OABSS indicated significant improvement in nocturia and urge incontinence at 3 and 6 months. Furthermore, mirabegron significantly relieved thirst (in 95.2% of cases) and constipation (in 87.5% of cases). Thus, mirabegron is considered useful for female patients aged ＞70 years who did not respond to treatment with an anticholinergic agent.