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タイトル: | Active surveillanceの適応と考えられた前立腺全摘症例の検討 |
その他のタイトル: | Clinical and Pathological Features of the Best Candidates for Active Surveillance-Retrospective Analysis of Patients with Radical Prostatectomy |
著者: | 井上, 隆太 橋本, 浩平 舛森, 直哉 竹内, 基 北村, 寛 長谷川, 匡 塚本, 泰司 |
著者名の別形: | Inoue, Ryuta Hashimoto, Kohei Masumori, Naoya Takeuchi, Motoi Kitamura, Hiroshi Hasegawa, Tadashi Tsukamoto, Taiji |
キーワード: | Prostate cancer Radical prostatectomy Active surveillance |
発行日: | Sep-2013 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 59 |
号: | 9 |
開始ページ: | 555 |
終了ページ: | 559 |
抄録: | To develop a more clinically relevant protocol and identify the best candidates for active surveillance (AS), we examined the pathological features of radical prostatectomy (RP) specimens of patients who met the Japanese AS protocol criteria. Of 342 patients who underwent RP between 2000 and 2010, 58 (17.0%) eligible for the Japanese AS protocol were retrospectively identified. Pathological features of biopsy specimens and RP specimens were compared to reveal the incidences of up-grading, up-staging and insignificant cancer. We also tried to identify preoperative clinical and pathological factors that accurately predicted the insignificant cancer in the surgical specimens. Up-grading (Gleason score ≥7) and upstaging (≥pT3) were observed in 32 (55.2%) and 6 (10.3%) patients, respectively. Insignificant cancer was observed in 19 (32.8%). Dominant tumors were located in the peripheral zone (PZ) in 34 (58.6%) patients and in the transition zone (TZ) in 24 (41.4%). Multivariate analysis revealed that prostate-specific antigen density <0.15 ng/ml/cm3 was a significant independent factor to predict insignificant cancer (odds ratio 6.70, p=0.036). Larger dominant tumors were associated more frequently with up-grading and up-staging (p=0.038 and p=0.021, respectively), and were more likely to be located in the TZ (P=0.027). Our results suggest that the risk of up-grading and up-staging should be considered in patients who met the Japanese protocol. Larger dominant tumors were associated more frequently with up-grading and up-staging. |
著作権等: | 許諾条件により本文は2014-10-01に公開 |
URI: | http://hdl.handle.net/2433/179130 |
PubMed ID: | 24113751 |
出現コレクション: | Vol.59 No.9 |
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