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Title: Two types of alpha satellite DNA in distinct chromosomal locations in Azara's owl monkey.
Authors: Prakhongcheep, Ornjira
Hirai, Yuriko
Hara, Toru
Srikulnath, Kornsorn
Hirai, Hirohisa  kyouindb  KAKEN_id
Koga, Akihiko  kyouindb  KAKEN_id
Author's alias: 古賀, 章彦
Keywords: centromere
centromeric constriction
satellite DNA
tandem repeats
Issue Date: Jun-2013
Publisher: Oxford University Press
Journal title: DNA research : an international journal for rapid publication of reports on genes and genomes
Volume: 20
Issue: 3
Start page: 235
End page: 240
Abstract: Alpha satellite DNA is a repetitive sequence known to be a major DNA component of centromeres in primates (order Primates). New World monkeys form one major taxon (parvorder Platyrrhini) of primates, and their alpha satellite DNA is known to comprise repeat units of around 340 bp. In one species (Azara's owl monkey Aotus azarae) of this taxon, we identified two types of alpha satellite DNA consisting of 185- and 344-bp repeat units that we designated as OwlAlp1 and OwlAlp2, respectively. OwlAlp2 exhibits similarity throughout its entire sequence to the alpha satellite DNA of other New World monkeys. The chromosomal locations of the two types of sequence are markedly distinct: OwlAlp1 was observed at the centromeric constrictions, whereas OwlAlp2 was found in the pericentric regions. From these results, we inferred that OwlAlp1 was derived from OwlAlp2 and rapidly replaced OwlAlp2 as the principal alpha satellite DNA on a short time scale at the speciation level. A less likely alternative explanation is also discussed.
Rights: © The Author 2013. Published by Oxford University Press on behalf of Kazusa DNA Research Institute.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
DOI(Published Version): 10.1093/dnares/dst004
PubMed ID: 23477842
Appears in Collections:Journal Articles

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