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dc.contributor.author | Kishino, Shigenobu | en |
dc.contributor.author | Takeuchi, Michiki | en |
dc.contributor.author | Park, Si-Bum | en |
dc.contributor.author | Hirata, Akiko | en |
dc.contributor.author | Kitamura, Nahoko | en |
dc.contributor.author | Kunisawa, Jun | en |
dc.contributor.author | Kiyono, Hiroshi | en |
dc.contributor.author | Iwamoto, Ryo | en |
dc.contributor.author | Isobe, Yosuke | en |
dc.contributor.author | Arita, Makoto | en |
dc.contributor.author | Arai, Hiroyuki | en |
dc.contributor.author | Ueda, Kazumitsu | en |
dc.contributor.author | Shima, Jun | en |
dc.contributor.author | Takahashi, Satomi | en |
dc.contributor.author | Yokozeki, Kenzo | en |
dc.contributor.author | Shimizu, Sakayu | en |
dc.contributor.author | Ogawa, Jun | en |
dc.contributor.alternative | 岸野, 重信 | ja |
dc.contributor.alternative | 清野, 宏 | ja |
dc.contributor.alternative | 國澤, 純 | ja |
dc.contributor.alternative | 有田, 誠 | ja |
dc.contributor.alternative | 新井, 洋由 | ja |
dc.contributor.alternative | 植田, 和光 | ja |
dc.contributor.alternative | 島, 純 | ja |
dc.contributor.alternative | 清水, 昌 | ja |
dc.contributor.alternative | 小川, 順 | ja |
dc.date.accessioned | 2013-10-21T04:36:26Z | - |
dc.date.available | 2013-10-21T04:36:26Z | - |
dc.date.issued | 2013-10-14 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | http://hdl.handle.net/2433/179285 | - |
dc.description | 腸内細菌の脂肪酸代謝を解明 -腸内細菌と食事のバランスによる生活習慣病予防への新たな視点-. 京都大学プレスリリース. 2013-10-15. | ja |
dc.description.abstract | In the representative gut bacterium Lactobacillus plantarum, we identified genes encoding the enzymes involved in a saturation metabolism of polyunsaturated fatty acids and revealed in detail the metabolic pathway that generates hydroxy fatty acids, oxo fatty acids, conjugated fatty acids, and partially saturated trans-fatty acids as intermediates. Furthermore, we observed these intermediates, especially hydroxy fatty acids, in host organs. Levels of hydroxy fatty acids were much higher in specific pathogen-free mice than in germ-free mice, indicating that these fatty acids are generated through polyunsaturated fatty acids metabolism of gastrointestinal microorganisms. These findings suggested that lipid metabolism by gastrointestinal microbes affects the health of the host by modifying fatty acid composition. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | National Academy of Sciences | en |
dc.rights | © 2013 National Academy of Sciences. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | biohydrogenation | en |
dc.subject | hydratase | en |
dc.subject | fatty acid isomerase | en |
dc.subject | conjugated linoleic acid | en |
dc.subject | lipid nutrition | en |
dc.title | Polyunsaturated fatty acid saturation by gut lactic acid bacteria affecting host lipid composition. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.identifier.volume | 110 | - |
dc.identifier.issue | 44 | - |
dc.identifier.spage | 17808 | - |
dc.identifier.epage | 17813 | - |
dc.relation.doi | 10.1073/pnas.1312937110 | - |
dc.textversion | author | - |
dc.identifier.pmid | 24127592 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131004_2.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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