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dc.contributor.authorMiyoshi, Takashija
dc.contributor.authorIto, Michihoja
dc.contributor.authorKitayama, Takashija
dc.contributor.authorIsomori, Sachikoja
dc.contributor.authorYamashita, Fumiyoshija
dc.contributor.alternative伊藤, 美千穂ja
dc.date.accessioned2013-10-22T00:20:47Z-
dc.date.available2013-10-22T00:20:47Z-
dc.date.issued2013-09-
dc.identifier.issn0918-6158ja
dc.identifier.urihttp://hdl.handle.net/2433/179289-
dc.description.abstractBenzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure–activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherThe Pharmaceutical Society of Japanja
dc.rights© 2013 The Pharmaceutical Society of Japanja
dc.subjectbenzylacetoneja
dc.subjectsedative effectja
dc.subjectinhalationja
dc.subjectstructure–activity relationshipja
dc.subjectfuzzy adaptive least squareja
dc.titleSedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activityja
dc.type.niitypeJournal Articleja
dc.identifier.ncidAA10885497ja
dc.identifier.jtitleBiological and Pharmaceutical Bulletinja
dc.identifier.volume36ja
dc.identifier.issue9ja
dc.identifier.spage1474ja
dc.identifier.epage1481ja
dc.relation.doi10.1248/bpb.b13-00250ja
dc.textversionpublisherja
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