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bpb.b13-00250.pdf | 1.6 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Miyoshi, Takashi | en |
dc.contributor.author | Ito, Michiho | en |
dc.contributor.author | Kitayama, Takashi | en |
dc.contributor.author | Isomori, Sachiko | en |
dc.contributor.author | Yamashita, Fumiyoshi | en |
dc.contributor.alternative | 伊藤, 美千穂 | ja |
dc.date.accessioned | 2013-10-22T00:20:47Z | - |
dc.date.available | 2013-10-22T00:20:47Z | - |
dc.date.issued | 2013-09 | - |
dc.identifier.issn | 0918-6158 | - |
dc.identifier.uri | http://hdl.handle.net/2433/179289 | - |
dc.description.abstract | Benzylacetone is released by heated agarwood, when inhaled it has a potent effect on reducing the locomotor activity of mice. This study investigated the relationships between the sedative activities of benzylacetone and its derivatives as well as the chemical structures of these compounds by comparing their activities in mice treated with a series of compounds. It was demonstrated that benzylacetone-like compounds had sedative activities and their intensities varied depending on the functional group in the carbon chain, the substituent in the benzene ring, and their combinations. A quantitative structure–activity relationship study was carried out using a series of 17 benzylacetone derivatives to determine the structural features with significant for the sedative activity. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Pharmaceutical Society of Japan | en |
dc.publisher.alternative | 日本薬学会 | ja |
dc.rights | © 2013 The Pharmaceutical Society of Japan | en |
dc.subject | benzylacetone | en |
dc.subject | sedative effect | en |
dc.subject | inhalation | en |
dc.subject | structure–activity relationship | en |
dc.subject | fuzzy adaptive least square | en |
dc.title | Sedative Effects of Inhaled Benzylacetone and Structural Features Contributing to Its Activity | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10885497 | - |
dc.identifier.jtitle | Biological and Pharmaceutical Bulletin | en |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1474 | - |
dc.identifier.epage | 1481 | - |
dc.relation.doi | 10.1248/bpb.b13-00250 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 23995659 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0918-6158 | - |
dc.identifier.eissn | 1347-5215 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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