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タイトル: | Age- and hypertension-dependent changes in retinal vessel diameter and wall thickness: an optical coherence tomography study. |
著者: | Muraoka, Yuki Tsujikawa, Akitaka Kumagai, Kyoko Akiba, Masahiro Ogino, Ken Murakami, Tomoaki Akagi-Kurashige, Yumiko Miyamoto, Kazuaki Yoshimura, Nagahisa |
著者名の別形: | 辻川, 明孝 |
発行日: | Oct-2013 |
出版者: | Elsevier Inc. |
誌名: | American journal of ophthalmology |
巻: | 156 |
号: | 4 |
開始ページ: | 706 |
終了ページ: | 714.e2 |
抄録: | [Purpose]To validate and evaluate the reliability of retinal vessel diameter measurements by optical coherence tomography (OCT). The effects of age and hypertension on vessel diameter were also examined. [Design]Prospective, cross-sectional study. [Methods]Two hundred thirty-eight eyes (238 subjects) with no ocular disease were included. Hypertension was present in 106 subjects and absent in 132 subjects. Spectralis HRA+OCT was used to scan a circular region around the optic disc. Outer and inner diameters of the 4 largest retinal arteries and veins were measured using OCT vascular wall reflections, and vessel wall thickness was calculated. [Results]Intervisit, interexaminer, and interevaluator intraclass correlation coefficients of randomly selected vessel measurements were all greater than 0.90. Mean inner arterial and venous diameters were 87.8 ± 9.4 μm and 113.7 ± 12.5 μm, respectively. The OCT-measured mean inner arterial and venous diameters were significantly correlated to fundus photography caliber measurements (P = .005 and P = .001, respectively). Arterial and venous wall thicknesses were 17.4 ± 2.4 μm and 13.7 ± 2.1 μm, respectively, both of which were highly correlated with subject age (arterial: r = 0.612, P < .001, venous: r = 0.455, P < .001). Additionally, both mean arterial and venous wall thicknesses were significantly greater in subjects with hypertension than in age-matched subjects without hypertension (P = .020 and P = .015, respectively). [Conclusions]Retinal vessel diameter measurements obtained with OCT were highly reproducible and vessel wall thicknesses, calculated using outer and inner diameter measurements, were significantly thickened by both aging and systemic hypertension. |
著作権等: | © 2013 Elsevier Inc. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/179294 |
DOI(出版社版): | 10.1016/j.ajo.2013.05.021 |
PubMed ID: | 23876868 |
出現コレクション: | 学術雑誌掲載論文等 |
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