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Title: Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors.
Authors: Imayoshi, Itaru  kyouindb  KAKEN_id  orcid (unconfirmed)
Isomura, Akihiro  kyouindb  KAKEN_id
Harima, Yukiko  KAKEN_id
Kawaguchi, Kyogo
Kori, Hiroshi
Miyachi, Hitoshi
Fujiwara, Takahiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Ishidate, Fumiyoshi
Kageyama, Ryoichiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 影山, 龍一郎
Issue Date: 31-Oct-2013
Publisher: American Association for the Advancement of Science
Journal title: Science
Volume: 342
Issue: 6163
Start page: 1203
End page: 1208
Abstract: The basic-helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are coexpressed by neural progenitor cells. Here, we found by time-lapse imaging that these factors are expressed in an oscillatory manner by mouse neural progenitor cells. In each differentiation lineage, one of the factors becomes dominant. We used optogenetics to control expression of Ascl1, and found that although sustained Ascl1 expression promotes neuronal fate determination, oscillatory Ascl1 expression maintains proliferating neural progenitor cells. Thus, the multipotent state correlates with oscillatory expression of several fate-determination factors, whereas the differentiated state correlates with sustained expression of a single factor.
Description: 神経幹細胞の自己複製および分化決定メカニズムの解明と、その操作に成功 -再生医療研究への貢献に期待-. 京都大学プレスリリース. 2013-11-01.
Rights: © 2013 American Association for the Advancement of Science.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1126/science.1242366
PubMed ID: 24179156
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