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タイトル: | Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors. |
著者: | Imayoshi, Itaru https://orcid.org/0000-0001-9728-481X (unconfirmed) Isomura, Akihiro Harima, Yukiko Kawaguchi, Kyogo Kori, Hiroshi Miyachi, Hitoshi Fujiwara, Takahiro https://orcid.org/0000-0001-5576-759X (unconfirmed) Ishidate, Fumiyoshi Kageyama, Ryoichiro https://orcid.org/0000-0002-5985-1120 (unconfirmed) |
著者名の別形: | 影山, 龍一郎 |
発行日: | 31-Oct-2013 |
出版者: | American Association for the Advancement of Science |
誌名: | Science |
巻: | 342 |
号: | 6163 |
開始ページ: | 1203 |
終了ページ: | 1208 |
抄録: | The basic-helix-loop-helix transcription factors Ascl1/Mash1, Hes1, and Olig2 regulate fate choice of neurons, astrocytes, and oligodendrocytes, respectively. These same factors are coexpressed by neural progenitor cells. Here, we found by time-lapse imaging that these factors are expressed in an oscillatory manner by mouse neural progenitor cells. In each differentiation lineage, one of the factors becomes dominant. We used optogenetics to control expression of Ascl1, and found that although sustained Ascl1 expression promotes neuronal fate determination, oscillatory Ascl1 expression maintains proliferating neural progenitor cells. Thus, the multipotent state correlates with oscillatory expression of several fate-determination factors, whereas the differentiated state correlates with sustained expression of a single factor. |
記述: | 神経幹細胞の自己複製および分化決定メカニズムの解明と、その操作に成功 -再生医療研究への貢献に期待-. 京都大学プレスリリース. 2013-11-01. |
著作権等: | © 2013 American Association for the Advancement of Science. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/179383 |
DOI(出版社版): | 10.1126/science.1242366 |
PubMed ID: | 24179156 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2013_1/131101_1.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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