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Title: MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
Authors: Horie, Takahiro  kyouindb  KAKEN_id
Nishino, Tomohiro  kyouindb  KAKEN_id
Baba, Osamu
Kuwabara, Yasuhide  kyouindb  KAKEN_id
Nakao, Tetsushi
Nishiga, Masataka
Usami, Shunsuke
Izuhara, Masayasu
Sowa, Naoya
Yahagi, Naoya
Shimano, Hitoshi
Matsumura, Shigenobu  kyouindb  KAKEN_id
Inoue, Kazuo  kyouindb  KAKEN_id  orcid (unconfirmed)
Marusawa, Hiroyuki  kyouindb  KAKEN_id
Nakamura, Tomoyuki
Hasegawa, Koji
Kume, Noriaki
Yokode, Masayuki  kyouindb  KAKEN_id
Kita, Toru
Kimura, Takeshi  kyouindb  KAKEN_id
Ono, Koh  kyouindb  KAKEN_id
Author's alias: 堀江, 貴裕
西野, 共達
尾野, 亘
Keywords: Biological sciences
Medical research
Issue Date: 3-Dec-2013
Publisher: Nature Publishing Group
Journal title: Nature Communications
Volume: 4
Thesis number: 3883
Abstract: MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports have indicated that miR-33, which is located within the intron of sterol regulatory element-binding protein (SREBP) 2, controls cholesterol homoeostasis and may be a potential therapeutic target for the treatment of atherosclerosis. Here we show that deletion of miR-33 results in marked worsening of high-fat diet-induced obesity and liver steatosis. Using miR-33−/−Srebf1+/− mice, we demonstrate that SREBP-1 is a target of miR-33 and that the mechanisms leading to obesity and liver steatosis in miR-33−/− mice involve enhanced expression of SREBP-1. These results elucidate a novel interaction between SREBP-1 and SREBP-2 mediated by miR-33 in vivo.
Description: 脂肪酸とコレステロール合成の切り替えスイッチの発見に成功 -安全な動脈硬化改善薬の開発に期待-. 京都大学プレスリリース. 2013-12-03.
Rights: © 2013 Macmillan Publishers Limited.
This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit
DOI(Published Version): 10.1038/ncomms3883
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