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タイトル: | MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice |
著者: | Horie, Takahiro Nishino, Tomohiro Baba, Osamu Kuwabara, Yasuhide Nakao, Tetsushi Nishiga, Masataka Usami, Shunsuke Izuhara, Masayasu Sowa, Naoya Yahagi, Naoya Shimano, Hitoshi Matsumura, Shigenobu Inoue, Kazuo https://orcid.org/0000-0001-7003-8635 (unconfirmed) Marusawa, Hiroyuki Nakamura, Tomoyuki Hasegawa, Koji Kume, Noriaki Yokode, Masayuki Kita, Toru Kimura, Takeshi Ono, Koh https://orcid.org/0000-0002-4163-980X (unconfirmed) |
著者名の別形: | 堀江, 貴裕 西野, 共達 尾野, 亘 |
キーワード: | Biological sciences Medical research |
発行日: | 3-Dec-2013 |
出版者: | Nature Publishing Group |
誌名: | Nature Communications |
巻: | 4 |
論文番号: | 3883 |
抄録: | MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA degradation. Recent reports have indicated that miR-33, which is located within the intron of sterol regulatory element-binding protein (SREBP) 2, controls cholesterol homoeostasis and may be a potential therapeutic target for the treatment of atherosclerosis. Here we show that deletion of miR-33 results in marked worsening of high-fat diet-induced obesity and liver steatosis. Using miR-33−/−Srebf1+/− mice, we demonstrate that SREBP-1 is a target of miR-33 and that the mechanisms leading to obesity and liver steatosis in miR-33−/− mice involve enhanced expression of SREBP-1. These results elucidate a novel interaction between SREBP-1 and SREBP-2 mediated by miR-33 in vivo. |
記述: | 脂肪酸とコレステロール合成の切り替えスイッチの発見に成功 -安全な動脈硬化改善薬の開発に期待-. 京都大学プレスリリース. 2013-12-03. |
著作権等: | © 2013 Macmillan Publishers Limited. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/ |
URI: | http://hdl.handle.net/2433/179546 |
DOI(出版社版): | 10.1038/ncomms3883 |
PubMed ID: | 24300912 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/131203_2.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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