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ファイル | 記述 | サイズ | フォーマット | |
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j.jphysparis.2013.04.007.pdf | 175.06 kB | Adobe PDF | 見る/開く |
タイトル: | The effects of prenatal and postnatal environmental interaction: Prenatal environmental adaptation hypothesis. |
著者: | Lee, Young-A Goto, Yukiori ![]() ![]() |
著者名の別形: | 後藤, 幸織 |
キーワード: | Evolution Neurodevelopment Prefrontal cortex Hippocampus Synaptic network microRNA Psychiatric disorders Epigenetics Cognitive function |
発行日: | Dec-2013 |
出版者: | Elsevier Ltd. |
誌名: | Journal of physiology, Paris |
巻: | 107 |
号: | 6 |
開始ページ: | 483 |
終了ページ: | 492 |
抄録: | Adverse antenatal maternal environments during pregnancy influence fetal development that consequently increases risks of mental health problems including psychiatric disorders in offspring. Therefore, behavioral and brain alterations caused by adverse prenatal environmental conditions are generally considered as deficits. In this article, we propose a novel hypothesis, along with summarizing a body of literatures supporting it, that fetal neurodevelopmental alterations, particularly synaptic network changes occurring in the prefrontal cortex, associated with adverse prenatal environmental conditions may be adaptation to cope with expected severe postnatal environments, and therefore, psychiatric disorders may be able to be understood as adaptive strategies against severe environmental conditions through evolution. It is hoped that the hypothesis presented in this article stimulates and opens a new venue on research toward understanding of biological mechanisms and therapeutic treatments of psychiatric disorders. |
著作権等: | © 2013 Elsevier Ltd. この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/179781 |
DOI(出版社版): | 10.1016/j.jphysparis.2013.04.007 |
PubMed ID: | 23624396 |
出現コレクション: | 学術雑誌掲載論文等 |
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