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dc.contributor.author | Hiraoka, Yoshinori | en |
dc.contributor.author | Matsuoka, Tatsuhiko | en |
dc.contributor.author | Ohno, Mikiko | en |
dc.contributor.author | Nakamura, Kazuhiro | en |
dc.contributor.author | Saijo, Sayaka | en |
dc.contributor.author | Matsumura, Shigenobu | en |
dc.contributor.author | Nishi, Kiyoto | en |
dc.contributor.author | Sakamoto, Jiro | en |
dc.contributor.author | Chen, Po-Min | en |
dc.contributor.author | Inoue, Kazuo | en |
dc.contributor.author | Fushiki, Tohru | en |
dc.contributor.author | Kita, Toru | en |
dc.contributor.author | Kimura, Takeshi | en |
dc.contributor.author | Nishi, Eiichiro | en |
dc.contributor.alternative | 西, 英一郎 | ja |
dc.date.accessioned | 2014-02-05T07:47:24Z | - |
dc.date.available | 2014-02-05T07:47:24Z | - |
dc.date.issued | 2014-02-04 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2433/180643 | - |
dc.description | 「体温恒常性維持のメカニズムの解明」に成功. 京都大学プレスリリース. 2014-02-04. | ja |
dc.description.abstract | Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis. Nrd1(-/-) mice show increased energy expenditure owing to enhanced BAT thermogenesis and hyperactivity. Despite these findings, Nrd1(-/-) mice show hypothermia and cold intolerance that are attributed to the lowered set point of body temperature, poor insulation and impaired cold-induced thermogenesis. Induction of β3-adrenergic receptor, PGC-1α and UCP1 in response to cold is severely impaired in the absence of NRDc. At the molecular level, NRDc and PGC-1α interact and co-localize at the UCP1 enhancer, where NRDc represses PGC-1α activity. These findings reveal a novel nuclear function of NRDc and provide important insights into the mechanism of thermoregulation. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | © 2014 Macmillan Publishers Limited. | en |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ | en |
dc.subject | Biological sciences | en |
dc.subject | Medical research | en |
dc.title | Critical roles of nardilysin in the maintenance of body temperature homoeostasis. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature communications | en |
dc.identifier.volume | 5 | - |
dc.relation.doi | 10.1038/ncomms4224 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 3224 | - |
dc.identifier.pmid | 24492630 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2013_1/140204_1.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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