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Title: Rapidly Progressive Cognitive Disturbances Due to Nonconvulsive Status Epilepticus Associated with a Cerebral Microbleed: Clinical Application of FDG-PET
Authors: Nakagami, Yukako  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7495-8957 (unconfirmed)
Sugihara, Genichi  kyouindb  KAKEN_id
Uemura, Kengo
Jingami, Naoto  kyouindb  KAKEN_id
Ueda, Keita  kyouindb  KAKEN_id
Takahashi, Ryosuke  kyouindb  KAKEN_id
Murai, Toshiya  kyouindb  KAKEN_id
Author's alias: 杉原, 玄一
Keywords: cerebral microbleeds
nonconvulsive status epileptics
positron-emission tomography
transient cognitive impairment
Issue Date: Feb-2014
Publisher: Japan Epilepsy Society
Journal title: Epilepsy & Seizure
Volume: 7
Issue: 1
Start page: 23
End page: 29
Abstract: Cerebral microbleeds (CMBs) usually produce no symptoms. We encountered a patient who developed cognitive decline and psychotic symptoms associated with nonconvulsive status epilepticus (NCSE), with presumptive epileptogenic focus possibly caused by a CMB. A 70-year-old man developed progressive cognitive disturbances including disorientation and hallucinations two months after a mild head injury. He was admitted to our hospital three months after the trauma, because of progression of symptoms. The first positron emission tomography (PET) with [18F]fluoro-2-deoxy-d-glucose (FDG) demonstrated intense FDG uptake in the left occipitoparietal region, in which a CMB was detected by T2∗-weighted magnetic resonance imaging (MRI). Electroencephalography showed continuous slow waves in the left occipital and parietal areas. After anticonvulsive therapy, his symptoms completely disappeared, accompanied by change in FDG uptake. Our case suggests that CMBs may be an epileptogenic focus of NCSE, and that FDG-PET is useful for the diagnosis of NCSE and assessment of therapeutic efficacy.
Rights: © 2014 The Japan Epilepsy Society
URI: http://hdl.handle.net/2433/185149
DOI(Published Version): 10.3805/eands.7.23
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