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j.celrep.2014.04.005.pdf | 2.55 MB | Adobe PDF | 見る/開く |
タイトル: | FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair |
著者: | Unno, Junya Itaya, Akiko Taoka, Masato Sato, Koichi Tomida, Junya Sakai, Wataru Sugasawa, Kaoru Ishiai, Masamichi Ikura, Tsuyoshi Isobe, Toshiaki Kurumizaka, Hitoshi Takata, Minoru |
著者名の別形: | 海野, 純也 高田, 穣 |
発行日: | 22-May-2014 |
出版者: | Elsevier BV |
誌名: | Cell Reports |
巻: | 7 |
開始ページ: | 1 |
終了ページ: | 9 |
抄録: | The Fanconi anemia (FA) pathway is critically involved in the maintenance of hematopoietic stem cells and the suppression of carcinogenesis. A key FA protein, FANCD2, is monoubiquitinated and accumulates in chromatin in response to DNA interstrand crosslinks (ICLs), where it coordinates DNA repair through mechanisms that are still poorly understood. Here, we report that CtIP protein directly interacts with FANCD2. A region spanning amino acids 166 to 273 of CtIP and monoubiquitination of FANCD2 are both essential for the FANCD2-CtIP interaction and mitomycin C (MMC)-induced CtIP foci. Remarkably, both FANCD2 and CtIP are critical for MMCinduced RPA2 hyperphosphorylation, an event that accompanies end resection of double-strand breaks. Collectively, our results reveal a role of monoubiquitinated FANCD2 in end resection that depends on its binding to CtIP during ICL repair. |
記述: | 小児の遺伝性疾患「ファンコニ貧血」病態の完全解明への一歩 ~キー分子FANCD2に会合するCtIPタンパク質の同定~. 京都大学プレスリリース. 2014-05-02. |
著作権等: | © 2014 Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
URI: | http://hdl.handle.net/2433/186786 |
DOI(出版社版): | 10.1016/j.celrep.2014.04.005 |
PubMed ID: | 24794430 |
関連リンク: | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2014/140502_2.htm |
出現コレクション: | 学術雑誌掲載論文等 |
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