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dc.contributor.author | Izumi, Hiroto | en |
dc.contributor.author | McCloskey, Asako | en |
dc.contributor.author | Shinmyozu, Kaori | en |
dc.contributor.author | Ohno, Mutsuhito | en |
dc.contributor.alternative | 大野, 睦人 | ja |
dc.date.accessioned | 2014-05-29T05:53:24Z | - |
dc.date.available | 2014-05-29T05:53:24Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/2433/187373 | - |
dc.description.abstract | The assembly of spliceosomal U snRNPs in metazoans requires nuclear export of U snRNA precursors. Four factors, nuclear cap-binding complex (CBC), phosphorylated adaptor for RNA export (PHAX), the export receptor CRM1 and RanGTP, gather at the m(7)G-cap-proximal region and form the U snRNA export complex. Here we show that the multifunctional RNA-binding proteins p54nrb/NonO and PSF are U snRNA export stimulatory factors. These proteins, likely as a heterodimer, accelerate the recruitment of PHAX, and subsequently CRM1 and Ran onto the RNA substrates in vitro, which mediates efficient U snRNA export in vivo. Our results reveal a new layer of regulation for U snRNA export and, hence, spliceosomal U snRNP biogenesis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | en |
dc.rights | © The Author(s) 2014. Published by Oxford University Press. | en |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.title | p54nrb/NonO and PSF promote U snRNA nuclear export by accelerating its export complex assembly. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00760269 | - |
dc.identifier.jtitle | Nucleic acids research | en |
dc.identifier.volume | 42 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 3998 | - |
dc.identifier.epage | 4007 | - |
dc.relation.doi | 10.1093/nar/gkt1365 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 24413662 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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