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タイトル: | 化学療法を施行した転移性尿路上皮癌症例における予後因子としての末梢血リンパ球数の検討 |
その他のタイトル: | Clinical Impact of Peripheral Lymphocyte Counts for Metastatic Urothelial Carcinoma Patients Treated with Chemotherapy |
著者: | 関田, 信之 西川, 里佳 藤村, 正亮 竹内, 信善 荻野, 寛子 柴田, 直樹 大村, 幸子 三上, 和男 |
著者名の別形: | Sekita, Nobuyuki Nishikawa, Rika Fujimura, Masaaki Takeuchi, Nobuyoshi Ogino, Hiroko Shibata, Naoki Omura, Sachiko Mikami, Kazuo |
キーワード: | Metastatic urothelial carcinoma Chemotherapy Lymphocyte |
発行日: | May-2014 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 60 |
号: | 5 |
開始ページ: | 215 |
終了ページ: | 219 |
抄録: | Pre-chemotherapeutic factors to assess the prognosis of patients with advanced urothelial carcinoma have not yet been completely established. The immune response of the host to the tumor is lymphocytedependent. However, the effect of lymphocytes on chemotherapy prognosis is unknown. In this study, we investigated the correlation between pre-chemotherapeutic lymphocyte counts and the clinical characteristics of urothelial carcinoma and determined the effectiveness of lymphocytes as a prognostic predictor for metastatic urothelial carcinoma treated with chemotherapy. Between April 2003 and March 2011, data from 34 patients withunresectable or metastatic urothelial carcinoma were retrospectively subjected to multivariate regression analysis to determine the patient characteristics with independent prognostic significance for survival. The median patient age was 71 ; 21 patients were male and 13 female. The number of primary tumors in the pelvis, ureter, and bladder were four, six, and 24, respectively. Seventeen patients underwent prior curative resections, and visceral metastases at chemotherapy were detected in 14 patients. The median lymphocyte count at chemotherapy was 1, 292/ml. Cancer-specific survival was significantly lower in patients withlymph ocyte counts <1, 000/ml than in patients with lymphocyte counts ≥1, 000/μl (p=0. 001). During multivariate analysis, visceral metastasis and lymphocyte counts were independent factors for predicting poor prognosis. In addition, lymphocyte counts of <1, 000/ml or positive visceral metastases also affected survival. This information may be useful for identifying patients who are likely to benefit from chemotherapy. |
著作権等: | 許諾条件により本文は2015/06/01に公開 |
URI: | http://hdl.handle.net/2433/187777 |
PubMed ID: | 24894856 |
出現コレクション: | Vol. 60 No. 5 |
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