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タイトル: | Roles of FGFs as Adipokines in Adipose Tissue Development, Remodeling, and Metabolism. |
著者: | Ohta, Hiroya Itoh, Nobuyuki |
著者名の別形: | 伊藤, 信行 |
キーワード: | adipocyte adipokine development FGF metabolism remodeling |
発行日: | 24-Feb-2014 |
出版者: | Frontiers |
誌名: | Frontiers in endocrinology |
巻: | 5 |
論文番号: | 18 |
抄録: | White and brown adipose tissues (BATs), which store and burn lipids, respectively, play critical roles in energy homeostasis. Fibroblast growth factors (FGFs) are signaling proteins with diverse functions in development, metabolism, and neural function. Among 22 FGFs, FGF1, FGF10, and FGF21 play roles as adipokines, adipocyte-secreted proteins, in the development and function of white and BATs. FGF1 is a critical transducer in white adipose tissue (WAT) remodeling. The peroxisome proliferator-activated receptor γ-FGF1 axis is critical for energy homeostasis. FGF10 is essential for embryonic white adipocyte development. FGF21 activates BAT in response to cold exposure. FGF21 also stimulates the accumulation of brown-like cells in WAT during cold exposure and is an upstream effector of adiponectin, which controls systemic energy metabolism. These findings provide new insights into the roles of FGF signaling in white and BATs and potential therapeutic strategies for metabolic disorders. |
著作権等: | © 2014 Ohta and Itoh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
URI: | http://hdl.handle.net/2433/187785 |
DOI(出版社版): | 10.3389/fendo.2014.00018 |
PubMed ID: | 24605108 |
出現コレクション: | 学術雑誌掲載論文等 |
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