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タイトル: | Effects of supplemental β-carotene on mucosal IgA induction in the jejunum and ileum of mice after weaning. |
著者: | Nishida, Keita Sugimoto, Miki Ikeda, Shuntaro Kume, Shinichi https://orcid.org/0000-0002-8759-8476 (unconfirmed) |
著者名の別形: | 久米, 新一 |
キーワード: | Supplemental β-carotene Jejunum Ileum IgA induction Weanling mice |
発行日: | 28-Jan-2014 |
出版者: | Cambridge University Press |
誌名: | The British journal of nutrition |
巻: | 111 |
号: | 2 |
開始ページ: | 247 |
終了ページ: | 253 |
抄録: | An adequate immune system is required to prevent diarrhoea in neonates, and IgA provides protection against microbial antigens on mucosal surfaces. Although β-carotene supplementation has been expected to enhance the retinoic acid (RA)-mediated immune response in neonates, the exact mechanism of the enhancement of mucosal IgA production in the small intestine by β-carotene is still unclear. In the present study, we investigated the effect of supplemental β-carotene on the concentrations of IgA, the numbers of IgA antibody-secreting cells (ASC) and the mRNA expressions of IgA C-region, CCL25, retinoid X receptor (RXR) α, retinoic acid receptor (RAR) α and RARγ in the jejunum and ileum of weanling mice. Weanling mice were fed rodent feed or 50 mg/kg β-carotene-supplemented rodent feed for 7, 14 or 21 d. The concentrations of IgA and the numbers of IgA ASC in the jejunum and ileum of mice increased markedly with age, and supplemental β-carotene increased the concentrations of IgA, the numbers of IgA ASC and the mRNA expressions of IgA C-region, CCL25 and RARγ in the jejunum after 14 and 21 d of treatment. Supplemental β-carotene increased the numbers of IgA ASC in the ileum after 14 and 21 d of treatment, but the concentrations of IgA in the ileum were not affected by β-carotene supplementation. The mRNA expressions of RXRα and RARα in the jejunum and those of RXRα and RARγ in the ileum after 21 d of treatment were enhanced by β-carotene supplementation. These results indicate that β-carotene supplementation in weanling mice is effective to enhance mucosal IgA induction in the jejunum or ileum and that the effects are mainly due to the RA-mediated immune response. |
著作権等: | © The Authors 2013. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/189086 |
DOI(出版社版): | 10.1017/S0007114513002195 |
PubMed ID: | 23830034 |
出現コレクション: | 学術雑誌掲載論文等 |
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