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Title: Effects of supplemental β-carotene on mucosal IgA induction in the jejunum and ileum of mice after weaning.
Authors: Nishida, Keita
Sugimoto, Miki  kyouindb  KAKEN_id
Ikeda, Shuntaro  kyouindb  KAKEN_id
Kume, Shinichi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-8759-8476 (unconfirmed)
Author's alias: 久米, 新一
Keywords: Supplemental β-carotene
Jejunum
Ileum
IgA induction
Weanling mice
Issue Date: 28-Jan-2014
Publisher: Cambridge University Press
Journal title: The British journal of nutrition
Volume: 111
Issue: 2
Start page: 247
End page: 253
Abstract: An adequate immune system is required to prevent diarrhoea in neonates, and IgA provides protection against microbial antigens on mucosal surfaces. Although β-carotene supplementation has been expected to enhance the retinoic acid (RA)-mediated immune response in neonates, the exact mechanism of the enhancement of mucosal IgA production in the small intestine by β-carotene is still unclear. In the present study, we investigated the effect of supplemental β-carotene on the concentrations of IgA, the numbers of IgA antibody-secreting cells (ASC) and the mRNA expressions of IgA C-region, CCL25, retinoid X receptor (RXR) α, retinoic acid receptor (RAR) α and RARγ in the jejunum and ileum of weanling mice. Weanling mice were fed rodent feed or 50 mg/kg β-carotene-supplemented rodent feed for 7, 14 or 21 d. The concentrations of IgA and the numbers of IgA ASC in the jejunum and ileum of mice increased markedly with age, and supplemental β-carotene increased the concentrations of IgA, the numbers of IgA ASC and the mRNA expressions of IgA C-region, CCL25 and RARγ in the jejunum after 14 and 21 d of treatment. Supplemental β-carotene increased the numbers of IgA ASC in the ileum after 14 and 21 d of treatment, but the concentrations of IgA in the ileum were not affected by β-carotene supplementation. The mRNA expressions of RXRα and RARα in the jejunum and those of RXRα and RARγ in the ileum after 21 d of treatment were enhanced by β-carotene supplementation. These results indicate that β-carotene supplementation in weanling mice is effective to enhance mucosal IgA induction in the jejunum or ileum and that the effects are mainly due to the RA-mediated immune response.
Rights: © The Authors 2013.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/189086
DOI(Published Version): 10.1017/S0007114513002195
PubMed ID: 23830034
Appears in Collections:Journal Articles

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