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dc.contributor.author | Sugawara, Tatsuya | en |
dc.contributor.author | Ganesan, Ponesakki | en |
dc.contributor.author | Li, Zhuosi | en |
dc.contributor.author | Manabe, Yuki | en |
dc.contributor.author | Hirata, Takashi | en |
dc.contributor.alternative | 菅原, 達也 | ja |
dc.date.accessioned | 2014-07-18T07:24:40Z | - |
dc.date.available | 2014-07-18T07:24:40Z | - |
dc.date.issued | 2014-06-19 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.uri | http://hdl.handle.net/2433/189093 | - |
dc.description.abstract | Siphonaxanthin is a specific keto-carotenoid in green algae whose bio-functional properties are yet to be identified. This review focuses on siphonaxanthin as a bioactive compound and outlines the evidence associated with functionality. Siphonaxanthin has been reported to potently inhibit the viability of human leukemia HL-60 cells via induction of apoptosis. In comparison with fucoxanthin, siphonaxanthin markedly reduced cell viability as early as 6 h after treatment. The cellular uptake of siphonaxanthin was 2-fold higher than fucoxanthin. It has been proposed that siphonaxanthin possesses significant anti-angiogenic activity in studies using human umbilical vein endothelial cells and rat aortic ring. The results of these studies suggested that the anti-angiogenic effect of siphonaxanthin is due to the down-regulation of signal transduction by fibroblast growth factor receptor-1 in vascular endothelial cells. Siphonaxanthin also exhibited inhibitory effects on antigen-induced degranulation of mast cells. These findings open up new avenues for future research on siphonaxanthin as a bioactive compound, and additional investigation, especially in vivo studies, are required to validate these findings. In addition, further studies are needed to determine its bioavailability and metabolic fate. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | en |
dc.rights | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.subject | angiogenesis | en |
dc.subject | apoptosis | en |
dc.subject | carotenoid | en |
dc.subject | inflammation | en |
dc.subject | green algae | en |
dc.subject | siphonaxanthin | en |
dc.title | Siphonaxanthin, a green algal carotenoid, as a novel functional compound. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Marine drugs | en |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 3660 | - |
dc.identifier.epage | 3668 | - |
dc.relation.doi | 10.3390/md12063660 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 24950294 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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