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タイトル: | The functional significance of newly born neurons integrated into olfactory bulb circuits. |
著者: | Sakamoto, Masayuki https://orcid.org/0000-0001-6458-113X (unconfirmed) Kageyama, Ryoichiro https://orcid.org/0000-0002-5985-1120 (unconfirmed) Imayoshi, Itaru https://orcid.org/0000-0001-9728-481X (unconfirmed) |
著者名の別形: | 坂本, 雅行 影山, 龍一郎 今吉, 格 |
キーワード: | neurogenesis main olfactory bulb accessory olfactory bulb granule cell periglomerular cell lateral inhibition behavior neural stem cell |
発行日: | 26-May-2014 |
出版者: | Frontiers |
誌名: | Frontiers in neuroscience |
巻: | 8 |
論文番号: | 121 |
抄録: | The olfactory bulb (OB) is the first central processing center for olfactory information connecting with higher areas in the brain, and this neuronal circuitry mediates a variety of odor-evoked behavioral responses. In the adult mammalian brain, continuous neurogenesis occurs in two restricted regions, the subventricular zone (SVZ) of the lateral ventricle and the hippocampal dentate gyrus. New neurons born in the SVZ migrate through the rostral migratory stream and are integrated into the neuronal circuits of the OB throughout life. The significance of this continuous supply of new neurons in the OB has been implicated in plasticity and memory regulation. Two decades of huge investigation in adult neurogenesis revealed the biological importance of integration of new neurons into the olfactory circuits. In this review, we highlight the recent findings about the physiological functions of newly generated neurons in rodent OB circuits and then discuss the contribution of neurogenesis in the brain function. Finally, we introduce cutting edge technologies to monitor and manipulate the activity of new neurons. |
著作権等: | © 2014 Sakamoto, Kageyama and Imayoshi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
URI: | http://hdl.handle.net/2433/189427 |
DOI(出版社版): | 10.3389/fnins.2014.00121 |
PubMed ID: | 24904263 |
出現コレクション: | 学術雑誌掲載論文等 |
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