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タイトル: Glycosylation-mediated targeting of carriers.
著者: Kawakami, Shigeru
Hashida, Mitsuru  kyouindb  KAKEN_id
著者名の別形: 川上, 茂
橋田, 充
キーワード: Macromolecular carriers
Liposomes
Targeting
Glycosylation
Drug delivery
発行日: 28-Sep-2014
出版者: Elsevier B.V.
誌名: Journal of controlled release : official journal of the Controlled Release Society
巻: 190
開始ページ: 542
終了ページ: 555
抄録: For safe and effective therapy, drugs should be delivered selectively to their target tissues or cells at an optimal rate. Drug delivery system technology maximizes the therapeutic efficacy and minimizes unfavorable drug actions by controlling their distribution profiles. Ligand-receptor binding is a typical example of specific recognition mechanisms in the body; therefore, ligand-modified drug carriers have been developed for active targeting based on receptor-mediated endocytosis. Among the various ligands reported thus far, sugar recognition is a promising approach for active targeting because of their high affinity and expression. Glycosylation has been applied for both macromolecular and liposomal carriers for cell-selective drug targeting. Recently, the combination of ultrasound exposure and glycosylated bubble liposomes has been developed. In this review, recent advances of glycosylation-mediated targeted drug delivery systems are discussed.
著作権等: © 2014 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/189750
DOI(出版社版): 10.1016/j.jconrel.2014.06.001
PubMed ID: 24915504
出現コレクション:学術雑誌掲載論文等

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