Downloads: 216

Files in This Item:
File Description SizeFormat 
j.jconrel.2014.06.001.pdf497.39 kBAdobe PDFView/Open
Title: Glycosylation-mediated targeting of carriers.
Authors: Kawakami, Shigeru
Hashida, Mitsuru  kyouindb  KAKEN_id
Author's alias: 川上, 茂
橋田, 充
Keywords: Macromolecular carriers
Liposomes
Targeting
Glycosylation
Drug delivery
Issue Date: 28-Sep-2014
Publisher: Elsevier B.V.
Journal title: Journal of controlled release : official journal of the Controlled Release Society
Volume: 190
Start page: 542
End page: 555
Abstract: For safe and effective therapy, drugs should be delivered selectively to their target tissues or cells at an optimal rate. Drug delivery system technology maximizes the therapeutic efficacy and minimizes unfavorable drug actions by controlling their distribution profiles. Ligand-receptor binding is a typical example of specific recognition mechanisms in the body; therefore, ligand-modified drug carriers have been developed for active targeting based on receptor-mediated endocytosis. Among the various ligands reported thus far, sugar recognition is a promising approach for active targeting because of their high affinity and expression. Glycosylation has been applied for both macromolecular and liposomal carriers for cell-selective drug targeting. Recently, the combination of ultrasound exposure and glycosylated bubble liposomes has been developed. In this review, recent advances of glycosylation-mediated targeted drug delivery systems are discussed.
Rights: © 2014 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/189750
DOI(Published Version): 10.1016/j.jconrel.2014.06.001
PubMed ID: 24915504
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.