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s00705-013-1618-6.pdf | 1.46 MB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Yoshida, Tomoyuki | en |
dc.contributor.author | Omatsu, Tsutomu | en |
dc.contributor.author | Saito, Akatsuki | en |
dc.contributor.author | Katakai, Yuko | en |
dc.contributor.author | Iwasaki, Yuki | en |
dc.contributor.author | Kurosawa, Terue | en |
dc.contributor.author | Hamano, Masataka | en |
dc.contributor.author | Higashino, Atsunori | en |
dc.contributor.author | Nakamura, Shinichiro | en |
dc.contributor.author | Takasaki, Tomohiko | en |
dc.contributor.author | Yasutomi, Yasuhiro | en |
dc.contributor.author | Kurane, Ichiro | en |
dc.contributor.author | Akari, Hirofumi | en |
dc.contributor.alternative | 吉田, 友教 | ja |
dc.contributor.alternative | 明里, 宏文 | ja |
dc.date.accessioned | 2014-09-22T04:15:01Z | - |
dc.date.available | 2014-09-22T04:15:01Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 0304-8608 | - |
dc.identifier.uri | http://hdl.handle.net/2433/189758 | - |
dc.description.abstract | In this study, we examined the dynamics of cellular immune responses in the acute phase of dengue virus (DENV) infection in a marmoset model. Here, we found that DENV infection in marmosets greatly induced responses of CD4/CD8 central memory T and NKT cells. Interestingly, the strength of the immune response was greater in animals infected with a dengue fever strain than in those infected with a dengue hemorrhagic fever strain of DENV. In contrast, when animals were re-challenged with the same DENV strain used for primary infection, the neutralizing antibody induced appeared to play a critical role in sterilizing inhibition against viral replication, resulting in strong but delayed responses of CD4/CD8 central memory T and NKT cells. The results in this study may help to better understand the dynamics of cellular and humoral immune responses in the control of DENV infection. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Vienna | en |
dc.rights | The final publication is available at Springer via http://dx.doi.org/10.1007/s00705-013-1618-6 | en |
dc.rights | この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. | ja |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Antibodies, Neutralizing/immunology | en |
dc.subject.mesh | CD4-Positive T-Lymphocytes/immunology | en |
dc.subject.mesh | CD8-Positive T-Lymphocytes/immunology | en |
dc.subject.mesh | Callithrix/immunology | en |
dc.subject.mesh | Callithrix/virology | en |
dc.subject.mesh | Dengue/immunology | en |
dc.subject.mesh | Dengue/virology | en |
dc.subject.mesh | Dengue Virus/immunology | en |
dc.subject.mesh | Immunity, Cellular/immunology | en |
dc.subject.mesh | Immunity, Humoral/immunology | en |
dc.subject.mesh | Immunologic Memory/immunology | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Natural Killer T-Cells/immunology | en |
dc.subject.mesh | Severe Dengue/immunology | en |
dc.subject.mesh | Severe Dengue/virology | en |
dc.subject.mesh | T-Lymphocytes/immunology | en |
dc.subject.mesh | Virus Replication/immunology | en |
dc.title | Dynamics of cellular immune responses in the acute phase of dengue virus infection. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00548901 | - |
dc.identifier.jtitle | Archives of virology | en |
dc.identifier.volume | 158 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 1209 | - |
dc.identifier.epage | 1220 | - |
dc.relation.doi | 10.1007/s00705-013-1618-6 | - |
dc.textversion | author | - |
dc.identifier.pmid | 23381396 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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