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dc.contributor.author | Hou, Zengye | en |
dc.contributor.author | Oishi, Shinya | en |
dc.contributor.author | Suzuki, Yamato | en |
dc.contributor.author | Kure, Tatsuhide | en |
dc.contributor.author | Nakanishi, Isao | en |
dc.contributor.author | Hirasawa, Akira | en |
dc.contributor.author | Tsujimoto, Gozoh | en |
dc.contributor.author | Ohno, Hiroaki | en |
dc.contributor.author | Fujii, Nobutaka | en |
dc.contributor.alternative | 大野, 浩章 | ja |
dc.date.accessioned | 2014-09-24T00:55:11Z | - |
dc.date.available | 2014-09-24T00:55:11Z | - |
dc.date.issued | 2013-05-28 | - |
dc.identifier.issn | 1477-0539 | - |
dc.identifier.uri | http://hdl.handle.net/2433/189820 | - |
dc.description.abstract | Pyrazolo[4, 3-b]indole derivatives have been designed as novel CK2 inhibitor compounds based on the binding mode analysis of a previously reported phenylpyrazole-type CK2 inhibitor. A series of pyrazolo[4, 3-b]indoles and related dihydropyrazolo[4, 3-b]indoles were efficiently prepared from simple starting materials using a gold-catalysed three-component annulation reaction as a key step. Several of the newly synthesized compounds displayed high levels of inhibitory activity, indicating that the pyrazolo[4, 3-b]indole core represents a promising scaffold for the development of potent CK2 inhibitors. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | en |
dc.rights | This journal is © The Royal Society of Chemistry 2013 | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject.mesh | Casein Kinase II/antagonists & inhibitors | en |
dc.subject.mesh | Casein Kinase II/metabolism | en |
dc.subject.mesh | Catalysis | en |
dc.subject.mesh | Dose-Response Relationship, Drug | en |
dc.subject.mesh | Gold/chemistry | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Indoles/chemical synthesis | en |
dc.subject.mesh | Indoles/chemistry | en |
dc.subject.mesh | Indoles/pharmacology | en |
dc.subject.mesh | Molecular Structure | en |
dc.subject.mesh | Protein Kinase Inhibitors/chemical synthesis | en |
dc.subject.mesh | Protein Kinase Inhibitors/chemistry | en |
dc.subject.mesh | Protein Kinase Inhibitors/pharmacology | en |
dc.subject.mesh | Pyrazoles/chemical synthesis | en |
dc.subject.mesh | Pyrazoles/chemistry | en |
dc.subject.mesh | Pyrazoles/pharmacology | en |
dc.subject.mesh | Structure-Activity Relationship | en |
dc.title | Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Organic & biomolecular chemistry | en |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 3288 | - |
dc.identifier.epage | 3296 | - |
dc.relation.doi | 10.1039/c3ob40223a | - |
dc.textversion | author | - |
dc.identifier.pmid | 23535832 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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