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Title: Association of longer QT interval with arterial waveform and lower pulse pressure amplification: the Nagahama Study.
Authors: Tabara, Yasuharu  kyouindb  KAKEN_id
Takahashi, Yoshimitsu  kyouindb  KAKEN_id
Kohara, Katsuhiko
Setoh, Kazuya
Kawaguchi, Takahisa
Terao, Chikashi  kyouindb  KAKEN_id
Igase, Michiya
Yamada, Ryo  kyouindb  KAKEN_id
Kosugi, Shinji  kyouindb  KAKEN_id
Sekine, Akihiro
Miki, Tetsuro
Nakayama, Takeo  kyouindb  KAKEN_id
Matsuda, Fumihiko
Author's alias: 田原, 康玄
Keywords: blood pressure
central blood pressure
hypertension
pulse pressure amplification
QRS interval
QT interval
Issue Date: Aug-2013
Publisher: Oxford University Press
Journal title: American journal of hypertension
Volume: 26
Issue: 8
Start page: 973
End page: 980
Abstract: [BACKGROUND] Central systolic blood pressure (cSBP) has been postulated to correlate closely with cardiovascular risk. Identifying factors associated with cSBP is therefore important. Prolonged QT interval is known to be associated with cardiovascular outcomes and might also be associated with the arterial waveform and cSBP. We investigated the possible associations between electrocardiogram wave interval and cSBP in general population samples. [METHODS] Brachial blood pressure and radial arterial waveform were measured simultaneously. Augmentation index (AIx) was calculated from the radial waveform as the ratio of the height of the late systolic peak to that of the first peak. cSBP was defined as the absolute pressure of the late systolic peak. [RESULTS] In the first panel (n = 8,085), QT interval was strongly association with AIx (r = 0.330; P < 0.001). This association remained significant even in the heart rate–adjusted analysis (r = 0.184; P < 0.001). Although subjects with a longer QT interval were older and had higher blood pressure, heart rate, and pulse wave velocity, multivariable analysis with adjustment for these covariables nevertheless identified longer corrected QT interval as an independent determinant of increased AIx and smaller pulse pressure amplification (PPa; brachial SBP minus cSBP) (β = −0.066; P < 0.001). This association was replicated in the independent second panel (n = 1,412) (β = −0.105; P < 0.001). In contrast, QRS interval was positively associated with PPa (β = 0.056; P < 0.001). [CONCLUSIONS] Longer QT interval and short QRS duration were significantly associated with arterial waveform and PPa. Our results provide a clue to the elucidation of unidentified mechanisms of the increased cardiovascular outcome and mortality risks in subjects with longer QT interval.
Rights: This is a pre-copyedited, author-produced PDF of an article accepted for publication in "American Journal of Hypertension" following peer review. The version of record "Yasuharu Tabara, Yoshimitsu Takahashi, Katsuhiko Kohara, Kazuya Setoh, Takahisa Kawaguchi, Chikashi Terao, Michiya Igase, Ryo Yamada, Shinji Kosugi, Akihiro Sekine, Tetsuro Miki, Takeo Nakayama, and Fumihiko Matsuda the Nagahama Study Group Association of Longer QT Interval With Arterial Waveform and Lower Pulse Pressure Amplification: The Nagahama Study Am J Hypertens (2013) 26 (8): 973-980 first published online April 18, 2013 doi:10.1093/ajh/hpt052" is available online at: http://ajh.oxfordjournals.org/content/26/8/973
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/189834
DOI(Published Version): 10.1093/ajh/hpt052
PubMed ID: 23598421
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