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Title: 化学療法が奏功した進行性前立腺線維肉腫の1例
Other Titles: A Case of Advanced Prostate Fibrosarcoma that Reacted Well to Chemotherapy
Authors: 横山, 仁  KAKEN_name
齋藤, 徹一  KAKEN_name
山岸, 貴裕  KAKEN_name
小川, 輝之  KAKEN_name
栗崎, 功己  KAKEN_name
加藤, 晴朗  KAKEN_name
石塚, 修  KAKEN_name
西澤, 理  KAKEN_name
Author's alias: Yokoyama, Hitoshi
Saito, Tetsuichi
Yamagishi, Takahiro
Ogawa, Teruyuki
Kurizaki, Yoshiki
Kato, Haruaki
Ishizuka, Osamu
Nishizawa, Osamu
Keywords: Prostate sarcoma
Issue Date: Sep-2014
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要 = Acta urologica Japonica
Volume: 60
Issue: 9
Start page: 451
End page: 454
Abstract: Prostate fibrosarcoma is an extremely rare tumor for which complete excision has been the mainstay of treatment. Although chemotherapy has been attempted in cases with positive surgical margins and/or advanced stage disease, the effectiveness of this therapy has not been established. Herein, we report a case of advanced prostate fibrosarcoma that reacted well to chemotherapy. A 40-year-old man was referred for treatment of a large prostatic tumor with multiple lung, liver, and bone metastases. Needle biopsy of the prostate revealed that the tumor was a high-grade undifferentiated sarcoma. Chemotherapy with doxorubicin and ifosfamide was administered. After five courses of chemotherapy, the primary prostate tumor decreased markedly, and the lung and liver metastases almost disappeared. Radical cystoprostatectomy and ileal conduit formation were performed. Pathological diagnosis was fibrosarcoma. Another three courses of doxorubicin and ifosfamide therapy were performed, and doxorubicin was replaced by etoposide because the maximum dose of doxorubicin was reached. However, the effectiveness of the second-line therapy was poor, and the tumor progressed again. The patient died of lung metastasis 15 months later.
Rights: 許諾条件により本文は2015/10/01に公開
PubMed ID: 25293801
Appears in Collections:Vol. 60 No. 9

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