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dc.contributor.author | Koga, Akihiko | en |
dc.contributor.author | Hirai, Yuriko | en |
dc.contributor.author | Terada, Shoko | en |
dc.contributor.author | Jahan, Israt | en |
dc.contributor.author | Baicharoen, Sudarath | en |
dc.contributor.author | Arsaithamkul, Visit | en |
dc.contributor.author | Hirai, Hirohisa | en |
dc.contributor.alternative | 古賀, 章彦 | ja |
dc.date.accessioned | 2014-11-04T06:09:40Z | - |
dc.date.available | 2014-11-04T06:09:40Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1340-2838 | - |
dc.identifier.uri | http://hdl.handle.net/2433/191075 | - |
dc.description.abstract | Alpha-satellite DNA (AS) is a main DNA component of primate centromeres, consisting of tandemly repeated units of ~170 bp. The AS of humans contains sequences organized into higher-order repeat (HOR) structures, in which a block of multiple repeat units forms a larger repeat unit and the larger units are repeated tandemly. The presence of HOR in AS is widely thought to be unique to hominids (family Hominidae; humans and great apes). Recently, we have identified an HOR-containing AS in the siamang, which is a small ape species belonging to the genus Symphalangus in the family Hylobatidae. This result supports the view that HOR in AS is an attribute of hominoids (superfamily Hominoidea) rather than hominids. A single example is, however, not sufficient for discussion of the evolutionary origin of HOR-containing AS. In the present study, we developed an efficient method for detecting signs of large-scale HOR and demonstrated HOR of AS in all the three other genera. Thus, AS organized into HOR occurs widely in hominoids. Our results indicate that (i) HOR-containing AS was present in the last common ancestor of hominoids or (ii) HOR-containing AS emerged independently in most or all basal branches of hominoids. We have also confirmed HOR occurrence in centromeric AS in the Hylobatidae family, which remained unclear in our previous study because of the existence of AS in subtelomeric regions, in addition to centromeres, of siamang chromosomes. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | en |
dc.rights | © The Author 2014. Published by Oxford University Press on behalf of Kazusa DNA Research Institute. | en |
dc.rights | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | en |
dc.subject | alpha-satellite DNA | en |
dc.subject | higher-order repeat | en |
dc.subject | centromere | en |
dc.subject | hominoids | en |
dc.subject | evolutionary origin | en |
dc.title | Evolutionary origin of higher-order repeat structure in alpha-satellite DNA of primate centromeres. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11095219 | - |
dc.identifier.jtitle | DNA research : an international journal for rapid publication of reports on genes and genomes | en |
dc.identifier.volume | 21 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 407 | - |
dc.identifier.epage | 415 | - |
dc.relation.doi | 10.1093/dnares/dsu005 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 24585002 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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