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Title: 鼠径リンパ節非触知(cN0) 陰茎癌症例のリンパ節転移因子の検討
Other Titles: Investigation of Prognostic Factors for Occult Inguinal Lymph Node Metastasis in Penile Cancer Patients with No Palpable or Visibly Enlarged Inguinal Lymph Node (cN0)
Authors: 湯村, 寧  KAKEN_name
服部, 裕介  KAKEN_name
春日, 純  KAKEN_name
高本, 大路  KAKEN_name
野口, 和美  KAKEN_name
佐々木, 毅  KAKEN_name
Author's alias: Yumura, Yasushi
Hattori, Yuusuke
Kasuga, Jun
Takamoto, Daiji
Noguchi, Kazumi
Sasaki, Takeshi
Keywords: Penile cancer
Lymphnode metastasis
EAU risk classification
Issue Date: Oct-2014
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要 = Acta urologica Japonica
Volume: 60
Issue: 10
Start page: 469
End page: 474
Abstract: We investigated the incidence of inguinal lymph node metastasis in 66 penile cancer patients with no palpable or visibly enlarged inguinal lymph nodes (cN0). Median follow up interval was 35. 7 months. During follow up, 14 patients (21.2%) had inguinal lymph node metastasis and 6 patients died of cancer. Five-year disease-free survival was 77.3%. Univariate analysis demonstrated that local tumor staging (T), differentiation, lymphovascular invasion (LVI), and tumor infiltration pattern (INF, Yamamoto-Kohama grading system) were associated with the incidence of inguinal lymphnode metastasis. Multivariate analysis demonstrated that only LVI was associated with incidence of inguinal lymph node metastasis (p=0.008, Hazard ratio 17.947). According to EAU risk classification, the incidence of inguinal lymph node metastasis in the low-risk group, intermediate risk group and high-risk group was 12.0, 17.6 and 55.6%, respectively. In conclusion, LVI is an independent prognostic factor for inguinal lymph node metastasis in cN0 penile cancer. Furthermore, EAU risk classification is valid judging from our cases and in incidence of inguinal lymph node metastasis. Either sentinel node biopsy or inguinal lymph node dissection is recommended in high and intermediate risk patient.
Rights: 許諾条件により本文は2015/11/01に公開
PubMed ID: 25391775
Appears in Collections:Vol. 60 No. 10

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